Sheet-like devices

专利摘要:
The invention relates to a preformed single sheet metal sheet device (10, 110, 210, 310, 410, 510, 610, 710, 810) for delivering an benefit agent to skin, hair or nails. The device is a cosmetic or therapeutic patch or mask. The device has a non-planar topography on at least one surface 14, 114, 214, 314, 414, 514, 614, 714, 814; 16, 116, 216, 316, 416, 516, 616, 716, And it pops out less. The present invention also includes a method of manufacturing the device.
公开号:KR20020027478A
申请号:KR1020027000208
申请日:2000-06-30
公开日:2002-04-13
发明作者:디크싱로버트스탠리；에레이폴라인제인；존슨테레사루이스；레블랭크마이클저드
申请人:데이비드 엠 모이어；더 프록터 앤드 갬블 캄파니；
IPC主号:

专利说明:

Sheet-type device {SHEET-LIKE DEVICES}
[1] Technical field
[2] The present invention relates to a preformed single sheet metal sheet device. To a preformed single sheet metal sheet device, in particular a patch or mask, comprising at least one polymeric gel former for delivering a benefit agent to the skin, hair or nail. The device is suitable for local delivery of one or more benefit agents and exhibits improved mechanical properties such as stiffness and resilience. Furthermore, the device of the present invention is modest and, if applicable, conforms to the contour of the target surface.
[3] Background technology
[4] Advantages of using patches or masking devices that include polymeric gel formers in place of creams and lotions, such as to treat cosmetically the skin, hair or nails, or to promote the treatment of burns or wounds are known in the prior art. A variety of cosmetic patches or devices are described as being useful for delivery of commercially available or skin care actives, such as vitamin activity, anti-acne active, water-dispersing agents, and the like. Patches and devices are described in the literature and are commercially available in the medical field as a useful means for transdermal administration of medicaments. However, many of these patches or devices have drawbacks in the form of physical products that are manifested as undesirable usage characteristics, as recognized by the consumer or wearer. For example, some patches or devices may be too moist and sticky because the patch or device containing the gellant does not form a solid gel structure and as a result the patch or device is difficult to handle and difficult to apply to the skin . Others have strong adhesion at attachment and removal, and tight and uncomfortable, many patches do not provide effective release and penetration of benefit agents.
[5] Some patches or devices require the formation of a site on the skin, which is not neat when applied. For example, US-A-4,291,025 relates to a thermally reversible agar gel topical dressing comprising 5-12% agar, 20-75% diethylene glycol and 100% water by weight and a method of making the dressing. The composition may additionally contain a gel enhancer and certain desired ingredients (e.g., vitamins, antibiotics). According to one aspect of US-A-4,291,025, a solid, high strength, obtainable agar gel is prepared and then divided into small pellets or pieces. According to another aspect, the sol is applied to the target skin and is cooled to convert the agar gel to a sol when heated to form a removable gel form.
[6] Moreover, some patches or devices are too dry and inelastic, and therefore do not conform well to the contours of the surface when they are applied. For example, EP-A-161 681 discloses a gel plate comprising an aqueous solution of polysaccharides and polyhydric alcohols. A preferred polysaccharide for the gel plate is a blend of carrageenan and gal-actomannan, or carrageenan alone. The composition optionally comprises medical components such as skin irritants, anti-inflammatory agents, analgesics and antibiotics. It is disclosed that the gel plate is not only transparent and inconspicuous, has an exhilarating sensation and good adhesive property, is sufficiently stretchable, stretchable and strong.
[7] Elasticity and stiffness are important features of gelled devices. WO 97/17944 discloses a mixture of polysaccharides and water (balance) containing soluble alginate (0.1-5%), agar (0.01-0.5%), pectin (0.01-0.5%), xanthan gum (0.05-1% Lt; RTI ID = 0.0 > a < / RTI > The gel material may be abundant in water-soluble or water-dispersible active ingredients. The gel material is processed to form a structured gel as described immediately above, which is easy to handle and very suitable for the skin surface.
[8] WO 90/14110 discloses a self-supporting slab, pad of size, shape and thickness, comprising water insoluble alginate and a precipitation inhibitor such as xanthan gum or xanthan gum combined with locust bean gum, Or in the form of a wafer. Gellan is also disclosed as another useful precipitation inhibitor. The precipitation inhibitor in the formulation may act as a gel-forming agent. The formulation optionally comprises an anti-inflammatory, or preservative, iodine. The slab or wafer form of the formulation is elastic and applied on a plastic backing to form an integrated surgical dressing with the gel exposed or covered with gauze.
[9] US-A-4,318,746 discloses a composition comprising at least 0.5% of a first polymer capable of being dispersed, dissolved or hydrated in hot water and capable of forming or forming a curable gel upon cooling, dissolved or hydrolyzed at the time of cooling without dissolving in hot water, To a gel comprising at least 2% of a second polymer compatible with the polymer and water. The document discloses gels which are, for example, hard, cohesive and adhesive and useful for topical administration of electrodes or medicaments. The summary of the document is that one of the advantages of the gel is that it is relatively hard and adhesive at temperatures of less than 60 to < RTI ID = 0.0 > 65 C. < / RTI >
[10] JP-A-63-200760 discloses a two layer patch comprising a gelled matrix and a support sheet (or backing). The substrate teaches that the skin-associated surface of the gelled matrix is preferably flat. Instead, the skin-associated surface may include a mesh-like alignment of the channel (FIG. 3), a mark of the logo (FIG. 2), a substantially parallel array of channels (FIG. 5) have. The gelled matrix comprises a protein (gelatin, casein, albumin or serecin) or a water-soluble polymer to which is added an inorganic filler, a wetting agent, possibly a binder and / or a cross-linking agent. A two-layered patch is produced by casting into a mold of a desired shape.
[11] WO 98/17287 relates to hollow resilient silicone buffers for the treatment of keloid and hypertrophic scars by developing a negative charge around the scar. The buffer can be made with structured silicone sheeting, and the term " textured " can be used as an irregular surface containing, for example, edges, concavities or related tissue features that may be regular or irregular in appearance and appearance Is defined. The organization teaches that the distribution of charge is heterogeneous. No method of organizing silicon seating has been disclosed.
[12] US-A-4,289,125 discloses a polymeric sheet for at least structured image dressing on the skin side surface. It is wisely taught to provide a reservoir for flotation debris and an adherent site. Image dressing to a textured surface on one or both surfaces is disclosed. 1D discloses a single thin sheet device in which both surfaces are textured. The fibrous textured sheet acts as a framework and is then cured to transport the polymer. The skeletal fiber sheet is then removed by solvent filtration, leaving the entire single sheet of thin, self-supporting polymeric sheet. Figures 5F-5I disclose stacked devices with one " textured " surface. This includes a gently surfaced polymeric film that is partially contained in the material that will impart the fibrous tissue to its surface. The material involved may be a non-coated or coated gauze or mesh or the above-mentioned fibrous sheet (with or without filtration of the skeleton sheet). Figure 6D illustrates a non-stacked implementation having one " organized " surface. The fibrous material is stretched to an appropriate surface to deliver a film layer of polymer that acts as a skeleton to form a continuous phase from the fibrous material to the polymer coating (see Fig. 6C). The fibrous material can then be filtered.
[13] WO94 / 02674 discloses a paper sheet comprising a layer of paper laminated to synthetic fibers, having a repeating pattern comprising two or more contoured contoured regions of the same thickness at the same time, or having regular or irregularly spaced pores To a dual-structured treatment pad. Dual organization allows for mild and intense cleansing from the same pad.
[14] WO 98/50085 relates, for example, to articles which are wound dressing or target strips, for example disposable rhomboid napkins. The article includes a backsize coating of a substrate and a matte finish that is structured to provide a low adhesion. The literature teaches that the surface of the mat finish on the wound dressing is achievable by " mechanical action " and less of the dressing when applied to the skin.
[15] US-A-5,026,446 relates to a physically worn target strip as a disposable rhombic napkin. Physical abrasion improves adhesion of the adhesive closure tab to the target strip.
[16] The patches or sheets from the cosmetic and pharmaceutical field provide advances in achieving the desired physical and usage properties, but the document is based on the assumption that the device has the desired mechanical properties of rigidity, rigidity and elasticity, as well as operability, non- There is no description of a self-organizing, pre-formed sheet-like device, which is a single thin plate, with desired usage characteristics of conformity to the contour of the surface.
[17] Surprisingly, it has been found that a solid preformed gel sheet, which, when applied, is not only flexible in conformity with the contour of the target surface, but also exhibits an appropriate amount of syneresis, can be formulated as a self-supporting high rigidity structure. The device according to the first aspect of the present application has a non-planar topography, the topography of which is selected according to the target application surface and facilitates their manipulation and application. For example, a thick ridge near the device periphery promotes ease of operability and robustness, while a thinner zone is more suited to the target surface in an increased curvature zone. Additionally or alternatively, in use, the textured surface on the surface of the device around the wearer's skin, hair or nail will make the device less noticeable. The desired physical properties are achieved by selecting the chemical composition and flow properties of the gelled device with reference to the relationship between stiffness and elasticity and the desired properties at the time of use are those in which there are two or more contoured contour areas that do not have the same average thickness simultaneously Surface topography and / or a suitably organized surface or surfaces.
[18] The preferred preformed single sheet thin sheet type device of the present invention exhibits a low level of melt migration which helps to moisten the device upon contact and provide a cooling sensation. The surface liquid facilitates adhesion of the device to the target surface, and thus avoids the need for additional glue or adhesive coated gas over the gelated features.
[19] The single thin sheet-like device of the present application does not require support or reinforcement with an occlusive or non-occlusive backing material that is often referred to as a gas. However, the gas, if present, can be combined with a single sheet metal sheet device and provide additional support or reinforcement. In addition, the gas may be used to prevent evaporation of the active ingredients, or it may serve as a means for adhering the device to the skin when the adhesive is coated in the vicinity thereof. The gas may be impregnated, bonded, or laminated to one surface of the device.
[20] EP-B-507,160 discloses a process wherein the drug holding layer comprises lidocaine and the adhesive gel base comprises water soluble, high molecular weight material 0.5% to 50%, water 20-70% and water retention 1% to 70% The present invention relates to an external preparation for application to skin comprising a drug-retaining layer disposed on a support. Suitable supports are described as resilient materials such as nonwoven fibers.
[21] The gas, if present to provide additional support or strengthening, should be compatible with gelling. If the gel is foliated from the gas, the gas is incompatible with the gel. Even when a gel composition having desired elasticity and rigidity is found, difficulties in matching the gel with the gas compatible with the gel property may also occur. The combination of a resilient gas and a resilient gel does not necessarily create a resilient patch or mask device. In addition to the foliar heating problem, many elastic gases often exhibit a porosity in which the wet gel infiltrates the gas and forms a strong gel network within the fiber. It is believed that the network reduces the resilience of the generated device. Moreover, the gas can not provide a patch or mask device with an inconspicuous appearance on skin, hair, or nails. This often depends on the choice of gas and its properties.
[22] Wherein the sheet-like device is preferably a patch or mask for cosmetic or therapeutic application.
[23] SUMMARY OF THE INVENTION
[24] The present invention is, in a first aspect, a single sheet-thin sheet-like device previously formed for delivering an benefit agent to the skin, hair or nail, the device having a periphery defining a primary and secondary space isolated surface; At least one beneficial agent and at least one polymeric gel former; RTI ID = 0.0 > non-planar < / RTI > topography on at least one of the primary and secondary surfaces.
[25] In a second aspect of the present invention there is provided a single sheet-thin sheet-like device previously formed for delivering an benefit agent to the skin, hair or nail, the device having a periphery defining a primary and secondary space isolated surface; At least one beneficial agent and at least one polymeric gel former; Wherein the non-planar topography has a non-planar topography on at least one of the primary and secondary surfaces, wherein the non-planar topography includes two or more contoured contoured regions that do not have the same average thickness simultaneously.
[26] In a third aspect of the present invention, there is provided a single sheet-thin sheet-like device previously formed for delivering an benefit agent to skin, hair or nails, comprising at least one beneficial agent and at least one polymeric gel-former; Wherein the primary surface is adjacent to the skin, hair or nail in use, the secondary surface has non-planar topography, and the non-planar topography is a negative surface of the tissue surface, Wherein the negative image of the tissue surface provides a device having a tissue defined as R _a in excess of 10 탆.
[27] The device of the present invention having an organized surface is preferably organized not only visually but also textured.
[28] The device of the present invention is suitable for topical application to skin, hair or nails. They provide excellent on-use properties such as non-closure, comfort, fit, elasticity, visual appearance, stiffness, ease of manipulation and conformity in topical applications. Moreover, the devices described herein form high rigid structures with good mechanical properties and elasticity and elasticity. Preferred devices of the present invention exhibit low levels of syneresis that further provide properties in the use of hydrogenation and moisturizing benefits in topical applications.
[29] In a fourth aspect of the present invention, there is provided a method of manufacturing a preformed single thin sheet-like device according to the first or second aspect of the present invention, the method comprising the steps of: (The negative image of the tissue surface has a tissue defined as R _a in excess of 10 탆); Or both; Providing a gel-forming mixture comprising at least one beneficial agent and at least one gelling polymeric gel-forming agent in a mold having at least one surface that is a negative image of each non-planar topography; And then gelling the gel-forming mixture. In a preferred embodiment, to stamp the textured surface on the opposite primary and secondary surfaces of the device, the mold has an opposing textured surface with a tissue defined as R _a in excess of 10 탆. More preferably, the mold is additionally provided with at least one surface of the device, preferably two or more contoured areas that do not simultaneously have the same average thickness on the skin, hair or nail end secondary surface Non-planar topography that includes < / RTI >
[30] In a fifth aspect, the present invention provides a method of manufacturing a single sheet-thin sheet-like device previously formed according to the first or third aspects of the present invention, wherein the primary mold surface is provided with one or more benefits Providing a gel-forming mixture comprising at least one gelling polymeric gel former and at least one gelling polymeric gel former; Contacting the secondary textured surface with the secondary device surface of the gel-forming mixture; Gelling the gel-forming mixture; And removing the tissue surface from the device.
[31] In a sixth aspect, the present invention provides a method for delivering one or more beneficial agents to skin, hair or nails, comprising contacting a device according to the first, second or third aspect of the present invention with a skin, hair or nail Wherein the device comprises at least one beneficial agent and at least one polymeric gel former.
[32] Brief Description of Drawings
[33] Figs. 1A, 1B and 1C are a plan view, a cross-section perspective view, and a perspective view of a first embodiment of a device according to the first or second aspect of the present invention.
[34] Figures 2 and 3 are cross-sectional views of secondary and tertiary embodiments of the device according to the first or second aspect of the present invention.
[35] 4 is a cross-sectional partial perspective view of a quadrature embodiment of a device according to the first, second or third aspect of the present invention.
[36] 5 is a cross-sectional partial perspective view of a secondary embodiment of a device according to the first or third aspect of the present invention.
[37] Figure 6 is a view of an example of the error implementation of a preformed single lamina sheet type device according to the first or second aspect of the present invention on a user's face.
[38] 7A and 7B are a plan view and a cross-sectional view of the device of Fig.
[39] Figure 8 is a schematic of a two-dimensional implementation of a device according to the first or second aspect of the present invention on a user's face.
[40] 9 is a plan view of the preformed single lamina sheet type device of Fig.
[41] Figure 10 is a schematic of a chiller implementation of a device according to the first or second aspect of the present invention on a user's face.
[42] 11 is a cross-sectional view of the preformed single lamina sheet type device of Fig.
[43] Figure 12 is a cross-sectional view of an eighth embodiment of a device according to the invention, in a third aspect, wherein the device is organized on a primary and a secondary surface.
[44] DETAILED DESCRIPTION OF THE INVENTION
[45] The preformed single sheet thin sheet type device of the present invention comprises at least one beneficial agent and at least one polymeric gel former, as well as various optional components, as shown below. All levels and ratios are by weight of the total composition of the device unless otherwise specified. When a gas is used as an adduct of the device, the total weight of the device composition is calculated without including the weight of the gas.
[46] The term " preformed " as used herein means that the device is manufactured in a product form having a predetermined thickness, shape and size, the device needing to be removed from the package and covering the target area with the product form, rubbing or coating Or it can be placed on the target surface or decorated. Here, the device is preferably packaged in a sealed protective wrapper.
[47] The term " sheet-like device " as used herein means that the device described is a cosmetic or medical patch or mask, the patch being a continuous sheet, its shape being predetermined according to the specific area of skin, hair or nail to be treated, Is a discontinuous sheet covering a face with a hole in the eyes, nose or mouth.
[48] As used herein, the term " single lamina " means that the described device is a self-supporting monolayer.
[49] As used herein, the term " non-planar topography " refers to a region in which two or more contoured contours are drawn that do not have the same average thickness simultaneously. Alternatively or additionally, the term "non-planar topography" refers to a textured surface that is a negative image of a textured surface, and a negative image of a textured surface has a texture defined by R _a of greater than 10 μm. As used herein, the term " R _a " means the mean surface-to-surface deviation from the highest plane, as described in more detail in the section entitled " Evaluation Method " below.
[50] Sphere " adjacent contoured regions that do not have the same average thickness at the same time " are visually discerned, and when a small amount of thickness variation at a particular point, such as averaging what is provided by the organization described herein, Refer to the section on which it is located.
[51] The term " water soluble " as used herein means the ability to dissolve a gelatinous polymeric gel former in an aqueous solution at room temperature or elevated temperature to form a continuous phase.
[52] The term " bilay phenomenon " as used herein means a method in which the gel contracts upon leaving with the exudation of the liquid. Without being limited by theory, gel compositions form a three-dimensional matrix that binds or encapsulates other components of the composition. It is believed that the syneresis involves the natural separation of the initial homogeneous system into its original gel phase and liquid. The exuded liquid is a solution, the composition of which depends on the composition of the original gel. When the device of the present invention is applied to a target area, the device loses some of its volume to release and permeate the gel matrix, e.g., the component bound in the moisture or benefit agent, towards the target area.
[53] The term " polysaccharide " as used herein means a natural or synthetic, linear or branched polymer of monosaccharide units, which when swollen at low dry concentrations expands and gels the aqueous phase.
[54] The term " rupture compressibility " as used herein is a measure of the resilience of a gel. The method is described in detail in the section titled " Evaluation Method " below.
[55] The term " bursting force " as used herein is a measure of gel stiffness. The method is described in detail in the section entitled " Evaluation Method " below.
[56] As used herein, the term " periodicity " refers to a pattern of repeating units and is a measure of the distance between the starting and ending points of the repeating pattern unit.
[57] Non-planar topography of the device of the present invention may or may not have periodicity. The preferred periodic pattern is sinusoidal, sawtooth or conical. The preferred periodicity is from about 0.1 mm to about 10 mm, preferably from about 0.5 mm to about 5 mm. If the device comprises organized primary and secondary surfaces, the patterns on each surface may be the same or different and each pattern may or may not have periodicity. If the patterns are all periodic, the periodicity can be the same or different. In an embodiment having the same periodicity, a periodic pattern can be displayed on both surfaces, so that the peaks on one surface can be directed to the opposite side, either directly to the peak, or to the opposite side. Preferably, the device crosses the pattern if it finds that it is visually less noticeable in a crossing pattern.
[58] In the drawings, like numerals are provided as similar parts.
[59] Figures 1a, 1b and 1c illustrate a primary embodiment of a preformed single lamina sheet type device according to the present invention, designated generally at 10. A cross-sectional perspective view of FIG. 1b is selected along line 1b-1b in FIG. 1a. The device 10 has a periphery 12 that defines the primary and secondary space isolated surfaces 14,16. Device 10 has a non-planar topography on the secondary surface 16. The non-planar topography includes a thick zone outlined in the form of a rim 18 adjacent to the periphery 12 and a thick zone outlined in the form of a ridge 20 intermediate the periphery 12, as well as a thin zone 22 outlined.
[60] In use, it is intended that the substantially planar primary surface 14 be adjacent to the user's skin, hair or nail. Of course, it would be advantageous to provide non-planar topography (not shown) on the primary and secondary surfaces 14,16. Likewise, non-planar topography may be provided only on the primary surface 14 (not shown). For example, the device 10 is suitable for delivering an benefit agent to a skin area beneath or near the user ' s eyes.
[61] Figures 1a, 1b and 1c may have any suitable size, depending on the intended use and the product characteristics. The device is of the form that widespreadly grows to a total dimension of about 60 mm x about 27 mm, as defined by the abstract rectangle surrounding the shape. The substantially increasing shape curves the primary and secondary vertices close to the primary side of the abstract rectangle (not shown). Device 10 has 13 mm, 17 mm, 20 mm, 23 mm, and 21 mm angles at angles of 22.5 °, 45 °, 90 °, 135 ° and 157.5 ° from the junction of the abstract rectangle's first vertical side and the abstract rectangle's lateral midline Dimension.
[62] Figure 2 illustrates a secondary embodiment of a preformed single lamina sheet type device according to the first or second aspect of the present invention, generally denoted 110. Device 110 has a perimeter 112 defining primary and secondary spaced isolated surfaces 114, 116, with device 110 having a thickened area contoured in the form of rim 118 adjacent to perimeter 112 on secondary surface 116, And the contoured thick and thin sections 118, 122 do not have the same average thickness at the same time. The rim 118 helps to prevent tearing of the device 110 during operation and a thin zone 122 that is more suitable for use on the user's skin, in the large curvature region. Preferably, at least the thin section 122 also has a non-planar topography on the secondary surface 116, which is a negative image of the tissue surface, and the negative image of the tissue surface has a R _a (Not shown).
[63] Figure 3 illustrates a tertiary implementation of a device according to the first or second aspects of the present invention, generally denoted 210. Device 210 has a periphery 212 defining primary and secondary spaced isolation 214 and 216 with device 210 having a thick section outlined in the form of a ridge 220 intermediate the periphery 212 and a thin section 222 contoured in proximity to periphery 212 . The ridge 220 provides greater rigidity and resilience to operability and the thin zone 222 is more suitable for large curved target surfaces in use.
[64] 4 illustrates a quadrature implementation which is a cross-sectional partial perspective view of a preformed single lamina sheet-like device according to the first, second or third aspects of the present invention, generally denoted as 310. Device 310 has primary and secondary spaced isolated surfaces 314 and 316 and device 310 has a plurality of contoured thick sections in the form of spaced ridges 320 in the middle of the periphery (not shown), and a plurality of contoured thin sections 322 Non-planar topography. ≪ RTI ID = 0.0 > As shown, there is no organization along the length of the ridge, even though the device is alternatively considered to be organized across the ridge. However, the exemplified non-planar topography may further comprise _a textured surface, which is a negative image of the textured surface, having a texture defined as R _a in excess of 10 탆.
[65] Figure 5 illustrates a secondary embodiment, which is a cross-sectional partial perspective view of a preformed single lamina sheet-like device according to the first or third aspects of the present invention, generally denoted as 410. The device 410 has primary and secondary spaced isolated surfaces 414, 416, wherein the primary surface 414 is adjacent to the skin, hair or nail in use and the secondary surface 416 has a tissue defined as R _a in excess of 10 탆, Non-planar topography that includes a textured surface that is a negative image of the non-planar topography. It will also be appreciated that the primary and / or secondary surfaces 414, 416 have non-planar topography (not shown) that includes two or more contoured areas that do not have the same average thickness simultaneously. Also, the primary surface 414 will be considered to have a non-planar topography (not shown) that includes a textured surface that is a negative image of the textured surface, optionally with a tissue defined as R _a in excess of 10 μm.
[66] Figures 6, 7a and 7b illustrate examples of the error of a single preformed thin sheet-like device according to the first or second aspects of the present invention, generally denoted 510. The cross-sectional view of Figure 7b is selected along lines 7b-7b of Figure 7a. The device 510 has an irregular periphery 512 that defines the primary and secondary space isolated surfaces 514, 516. Device 510 has a non-planar topography that includes thin and thick areas 522, 524, each with two contoured contours, which do not have the same average thickness at the same time. In this embodiment, the non-planar topography is on the secondary surface 516. The thin section 522 is more suitable for the nose area-large curved area in use.
[67] Figures 8 and 9 illustrate a sixteen embodiment of a preformed single lamina sheet type device according to the first or second aspects of the present invention, generally denoted 610. Device 610 is a mask that is formed and dimensioned to substantially cover the user ' s face, has primary and secondary spaced isolated surfaces 614, 616, and device 610 has two or more adjacent contours Has a non-planar topography on a secondary surface 616 that includes thin and thickened areas 622, 624 drawn. Device 610 also includes pored holes 626 formed and sized to receive the user's eyes, nose, and mouth. The thin region 622 is space-isolated to the periphery 612 adjacent to the cut region 628. [ In use, as illustrated in Fig. 8, a single sheet-thin sheet-like device 610, previously formed in the form of a mask, is brought into contact with an adjacent thin section 622 to substantially cover the user ' s face to deliver one or more benefit agents to the facial skin do.
[68] Figures 10 and 11 illustrate a chiller implementation of a preformed single lamina sheet type device according to the first or second aspects of the present invention, generally denoted as 710. Device 710 is a dimensioned mask that is formed to substantially cover the user ' s face. Adjacent slits 730 are provided adjacent to the periphery 712. The device has a non-planar topography on the secondary surface 716, and the non-planar topography includes thin and thick glands 722, 724 each having two or more contiguous contours drawn that do not have the same average thickness at the same time. The thin section 722, in use, is adjacent to the user's eyes and nose / mouth area for the convenience of the user. Device 710 also includes slits 732 and pores 726, each formed and dimensioned to receive a user's nose and mouth and eyes, respectively. In use, the opposing surfaces of the peripheral slits 730 are disposed relative to one another such that a preformed single sheet-thin sheet-like device 710 in the form of a mask substantially covers the user's face.
[69] Fig. 12 illustrates an embodiment of the eighth embodiment, which is a device according to the first, second and third aspects of the present invention, generally denoted 810. Device 810 has a peripheral 812 that defines primary and secondary spaced isolated surfaces 814, 816 and device 810 has a thickened area contoured in the form of rim 818 in the form of rim 818 adjacent to peripheral 812 on secondary surface 816, , The outlined thick and thin sections 818, 822 do not have the same average thickness at the same time. Additionally, the device has _a textured surface on the primary and secondary surfaces 814, 816, which is a negative image of the textured surface, having a texture defined by R _a in excess of 10 탆.
[70] Alternatively, or in addition, the non-planar topography of the patch or mask device 10, 110, 210, 310, 410, 510, 610, 710, 810 may include symbols (not shown). The symbol may take the form of a brand name, for example a logo device and / or a series of alphabetic characters.
[71] Preferably, a non-planar topography is provided on the secondary surface of the device (in use, at the user's skin, hair or nail end, in use), which is a textured surface or two or more contoured zones or all of which do not have the same average thickness at the same time do. More preferably, non-planar topography, in addition to non-planar topography, is provided on the primary surface of the device, wherein the non-planar topography, in addition to two or more contoured regions and organized regions that do not have the same average thickness at the same time, (In use, on the user's skin, hair or nail end).
[72] Polymeric gel formers
[73] As an essential component of the preformed single sheet thin sheet-like device described herein, the device comprises at least one polymeric gel former. Typically, the preformed sheet-like device of the present invention comprises less than 70%, preferably less than 50%, more preferably less than 30%, and especially less than 10% of the total polymeric gel formers.
[74] One or more polymeric gel formers may be naturally or synthetically derived. The one or more polymeric gel formers may be self-supporting or may have only gel form in combination with other materials. Alternatively, one or more polymeric gel formers may be cross-linked physically or chemically.
[75] The polymeric gel formers may be self-gelling or may have only gel form in combination with other materials such as sugars, alcohols or monovalent or polyvalent salts. The monovalent or polyvalent salt may additionally serve as a gel fortifier imparting added stiffness to the preformed single lamina sheet type device of the present invention. Suitable cations can be selected from monovalent or polyvalent cations, such as potassium, sodium, ammonium, zinc, aluminum, calcium and magnesium ions, or mixtures thereof. Suitable anions associated with the cations can be selected from chloride, citrate, sulfate, carbonate, borate and phosphate anions, or mixtures thereof.
[76] Physical crosslinking refers to a polymer that is not a chemical covalent bond but has a crosslinked nature that is a physical property that is a region within a highly crystalline device or a region with a high glass transition temperature. Chemical crosslinking refers to polymers that are linked by chemical bonds. Preferably, the polymer is chemically crosslinked by radiation techniques such as heat-, E-beam-, UV-, gamma or microwave radiation. Also, when chemical cross-linking is to be formed in the system, a multifunctional cross-linking agent and / or a free radical initiator may be present in the premix to initiate cross-linking during replication. The components may preferably be present in an amount of up to 5% by weight.
[77] The polymeric gel formers are water-soluble or water-insoluble. Preferably, the at least one polymeric gel former is a water soluble gel former. The polymeric gel formers alternatively comprise a water insoluble polymeric gel former and include silicone polymeric gel formers / silicon (organopolysiloxane resins) or block copolymer thermoplastic elastomers.
[78] The water-insoluble polymeric gel former
[79] A water soluble hydroxyl functional organopolysiloxane comprising silicon with R ₃ SiO _1/2 siloxane units and SiO _4/2 wherein R is a monovalent radical selected from hydrocarbons and hydrogenated hydrocarbon radicals of 1 to 20 carbon atoms Can be described as a resin. In the names R ₃ SiO _1/2 and SiO _4/2 , 1/2 and 4/2 represent the number of half bonds on the molecule shown. For example, in R ₃ SiO _1/2, there is a ½ bond on oxygen and the other half is bound to some other atom. Such groups may also be described as follows:
[80]
[81] Similarly, SiO _4/2 has 4 1/2 bonds in the indicated molecule and the other half of each bond is bonded to some other molecule. Such groups may also be described as follows:
[82]
[83] The term " soluble resin " as used herein means that the gelled organopolysiloxane can be substantially completely dissolved in a hydrocarbon liquid such as benzene, toluene, xylene, heptane, etc. or in a silicone liquid such as a cyclic or linear polydiorganosiloxane do. Preferably the resin is soluble in a silicone fluid.
[84] In the formula for the silicone resin, R represents a monovalent radical selected from hydrocarbon and halogenated hydrocarbon radicals, preferably having less than 20 carbon atoms, and most preferably from 1 to 10 carbon atoms. Examples of suitable R radicals are alkyl radicals such as methyl, ethyl, propyl, pentyl, octyl, undecyl, octadecyl and the like; An alicyclic radical such as cyclohexyl; Aryl radicals such as phenyl, tolyl, xylyl, benzyl, alpha-methylstyryl, 2-phenylethyl and the like; Alkenyl radicals such as vinyl; And chlorinated hydrocarbon radicals such as 3-chloropropyl, dichlorophenyl, and the like.
[85] In order to enhance the solubility of the silicone resin in the silicone fluid, it is preferred to select the predominant organic radical of the silicone resin that matches the predominant organic radical of the silicone fluid. In the formula for the silicone resin, preferably at least 1/3, and more preferably substantially all of the R radicals are methyl radicals. Examples of preferred R ₃ SiO _1/2 siloxane units include Me ₃ SiO _1/2 and PhMe ₂ SiO _1/2 and Ph ₂ MeSiO _1/2 wherein Me represents methyl and Ph represents phenyl.
[86] It is preferred that the molar ratio of R ₃ SiO _1/2 siloxane unit to SiO _4/2 unit individually has a molar ratio of 0.5 to 1.2. It is more preferable that the molar ratio of R ₃ SiO _1/2 siloxane unit to SiO _4/2 unit is 0.6 to 0.8.
[87] Silicone resins can be prepared by well known methods. A-2,676,182 (Daudt et al.), Which is modified by US-A-3,627,851 (Brady) and US-A-3,772,247 (Flannigan); Each of the patents is incorporated herein by reference for teaching a method of making a water-soluble organopolysiloxane useful in the preformed single lamina sheet type device of the present invention. The resulting resin can be used without further modification or capped with a trialkylsilyl group to reduce the silanol content. This can be accomplished by well-known methods, such as the reaction of a resin with a compound such as trimethylchlorosilane or hexamethyldisilazane.
[88] The silicone fluid is preferably a hydroxyl terminated polysiloxane polymer. The repeat units of the silicone fluid are R ₂ SiO _2/2 (wherein R is independently selected from the same hydrocarbon and halogenated radicals defined above for the silicone resin) siloxy units. Typically, the silicone fluid may consist of a homopolymer or a copolymer, or it may be a mixture of two or more such polymers. The silicone fluid may be liquid or gum at 25 占 폚. It is preferably a methyl radical which is at least 50%, preferably at least 85%, of the organic radicals along the chain of silicone fluid and which can be distributed to the silicone fluid in any way. In addition, the silicone fluid may comprise up to about 10 mole% of the siloxane branched site.
[89] It is preferable to use the silicone resin in an amount of about 40 to 70 parts by weight in a single sheet-thin sheet type device that is formed in advance, and about 30 to about 60 parts by weight of the silicone fluid is used, wherein the total amount of the silicone resin and the fluid is 100 parts . It is generally preferred to use about 50 to 60 parts by weight of silicone resin and correspondingly about 40 to 50 parts by weight of silicone fluid, wherein the total weight portion is 100 parts by weight. A single sheet-thin sheet-like device previously formed by blending or condensing a silicone resin and a silicone fluid can be manufactured. Methods of condensing silicone resins and silicone fluids are well known.
[90] One preferred class of silicone resins includes trimethylsilyl terminated polysiloxane resins such as silicon-bonded hydroxyl radicals and containing about 0.6 to 0.9 triorganosiloxane units per each tetrafunctional siloxy unit present in the copolymer inherent in the ratio of the formula R ¹ ₃ SiO _1/2 4 of the tree organo siloxy units of the formula SiO _4/2, and of (wherein R ¹ is a monovalent organic radical independently selected from hydrocarbon radicals having 1 to 6 carbon atoms) A silicone resin composed of a benzene-soluble resin copolymer composed of functional siloxy units; And a mixture of silanol terminated capped polydiorganosiloxane fluids such as polydimethylsiloxane fluids. US-A-2,736,721 (Dexter et al.) And US-A-2,814,601 (Currie et al.) Are incorporated herein by reference in their entirety.
[91] Another suitable class is that of US-A-2,857,356 (Goodwin, Jr.), incorporated herein by reference, or a resin similar to that of Goodwin. US-A-2,857,356 discloses (i) a cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate, containing a number of silicon bonded hydroxy groups; And (ii) a linear high viscosity organopolysiloxane fluid containing a silicon-bonded hydroxy group.
[92] The silicone resin (i) and silicone fluid (ii) may optionally be condensed according to the process as described in CA-A-711,756 (Pail), which patent is incorporated herein by reference. In the condensation reaction, the silicone resin (i) and the silicone fluid (ii) are mixed in the presence of a catalytic amount of a silanol condensation catalyst, and then the silicone resin (i) and the silicone fluid (ii) To < / RTI > 20 hours. Examples of silanol condensation catalysts are primary, secondary and tertiary amines, carboxylic acids and quaternary ammonium salts of these amines.
[93] Another class is described in US-A-4,591,622 and 4,584,355, US-A-4,585,836 (Homan et al), and US-A-4,655,776 (Woodard ), Etc.). Generally, it consists of a blend of (i) a silicone resin chemically treated to reduce the silicon-bonded hydroxyl content of the blend and (ii) a silicone fluid. Which may optionally be condensed prior to chemical treatment as described above.
[94] The silicone polymeric gel formers should not be fused with a silicone rubber that is not useful for such use. Silicone polymeric gel formers generally contain fillers free of fillers or lower (less than 5%) fillers. In contrast, typically the silicone rubber contains about 15 to 35% filler. Generally, fillers are not required in high amounts in polymeric silicone gel formers, and high content often causes the silicone polymeric gel formers to lose stickiness and adhesion and increase the dynamic viscosity to form silicone polymeric gel formers Which makes it difficult to apply a coating.
[95] Other classes of suitable silicone polymeric gel formers are described in FR-A-2 735 024 and EP-A-0 764 441, each of which is incorporated herein by reference.
[96] Another alternative non-water soluble polymeric gel former may be an ABA block copolymer such as a block copolymer thermoplastic elastomer such as a styrene-olefin-styrene block copolymer or an ethylene-propylene block copolymer. More preferably such polymers include hydrogenated grades of styrene / ethylene-butylene / styrene (SEBS), styrene / isoprene / styrene (SIS), and styrene / ethylene-propylene / styrene (SEPS).
[97] Water-soluble polymeric gel formers
[98] Water-soluble polymeric gel formers for use in the present invention are selected from synthetic or natural polymers and mixtures thereof. Generally, the preformed sheet-like device of the present invention comprises less than 50% by weight, more preferably less than 30% by weight and particularly preferably less than 20% by weight based on the total weight of the water-soluble polymeric gel-forming agent.
[99] Synthetic Polymers : Synthetic polymers suitable for use herein include non-ionic water-soluble polymers; Acrylic acid based polymers or derivatives thereof; Or cellulose derivatives; And mixtures thereof. Synthetic polymers useful herein can be distinguished by their charge or constituent monomers. It should be understood, however, that the classification herein is for convenience only and may be duplicated between categories.
[100] Nonionic Water Soluble Polymers : Nonionic synthetic polymers suitable for use herein include, but are not limited to, polydimethylacrylamide, polyvinylpyrrolidone, polyethylene glycol monomethacrylate, poly-2-ethyl-2-oxazoline, polyvinyl alcohol, Copolymers of methyl vinyl ether and maleic anhydride, copolymers of ethylene and maleic anhydride, and mixtures thereof, as well as copolymers of polyvinyl ether, polyvinyl ether and polyvinylpyrrolidone, and derivatives thereof. The uncrosslinked polymer may be selected from the group consisting of vinyl alcohol, vinyl ethers and copolymers thereof, carboxyvinyl monomers, vinyl ester monomers, esters of carboxyvinyl monomers, vinylamide monomers, hydroxyvinyl monomers, amines or cationic vinyl monomers containing quaternary groups, N-vinyl lactam monomers and sulfonated polymers such as acrylamide sulfonated polymers, and mixtures thereof. Alternatively, the uncrosslinked polymer can be derived from homopolymers or copolymers of polyvinyl ethers, or half esters of maleic esters. Similarly, any other compatible polymeric monomer unit may be used, for example, as a copolymer, such as polyvinyl alcohol and polyacrylic acid or ethylene and vinyl acetate.
[101] Acrylic acid-based polymers or derivatives thereof : Suitable acrylic acid-based polymers or derivatives thereof include polymers of acrylic acid, hydroxyethylmethylacrylate, methoxydiethoxyethylmethacrylate, and hydroxydiethoxyethylmethacrylate; Salts of polyacrylic acids such as ammonium polyacrylate and sodium polyacrylate; Polymers of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) or salts thereof; Copolymers of acrylamide and N, N'-methylenebisacrylamide; And polyacrylamide, or mixtures thereof. More suitable polymers for use herein are the copolymers of one or more comonomers described in US-A-5,804,107, line 14, paragraphs 36 to 67 and line 15 to lines 1 to 34 and 2-hydroxyethyl &Quot; HEMA " based copolymers containing copolymers of methacrylate (" HEMA ").
[102] Cellulose derivatives : Examples of suitable cellulose derivatives for use herein include carboxymethyl hydroxyethyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, Hydroxypropylcellulose, methylcellulose, sodium methylcellulose, hydroxypropylmethylcellulose, methylhydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Also useful herein are alkyl substituted celluloses. In such a polymer, the hydroxy group of the cellulose polymer is hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose that is further modified with a C ₁₀ -C ₃₀ linear or branched alkyl group via an ether linkage . Typically, the polymer is a C ₁₀ -C ₃₀ linear or branched alcohol and an ether of hydroxyalkylcellulose. Examples of alkyl groups useful herein are stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (i.e., alkyl groups derived from alcohol of coconut oil), palmityl, oleyl, linoleyl, Linoleyl, linoleyl, ricinoleyl, behenyl, and mixtures thereof. Preferred among the alkylhydroxyethylcellulose ethers are substances given by CTFA which is cetylhydroxyethylcellulose, which is an ether of cetyl alcohol and hydroxyethylcellulose. This material is available from Aqualon Corporation under the tradename Natrosol CS Plus.
[103] Natural Polymers : Natural polymers suitable for use herein include gelatins, polysaccharides, and mixtures thereof. The polysaccharides for use herein are preferably red alga polysaccharides; Glucomannan; Galactomannan; Fermenting polysaccharides, or derivatives thereof; Brown algal polysaccharide; Extracts from marine invertebrates; Starch or derivatives thereof; Natural fruit extract; Plant fiber derivatives; kelp; Natural plant extrudate; Resin gum; And mixtures thereof. When the device herein contains more than one polysaccharide as the water soluble polymeric film forming agent (s), the device will contain less than 10%, preferably less than 5%, and more preferably less than 3% Polysaccharides or mixtures thereof.
[104] Gelatin : When gelatin is used in the devices herein high molecular weight gelatin is combined with low molecular weight to control solubility. Gelatine having a low molecular weight of 20,000 or less has poor gelling ability.
[105] Brown alga polysaccharides : polysaccharides classified as brown alga polysaccharides are separated into extracts from various phaebophyceae. Suitable brown algal polysaccharides for use herein include algin, alginic acid, ammonium alginate, calcium alginate, potassium alginate, sodium alginate, propylene glycol alginate, and mixtures thereof.
[106] Red algae polysaccharides : polysaccharides classified as red algae polysaccharides are isolated from marine plant species belonging to Rhodo-phyceae family. Red algae polysaccharides provide mechanical stiffness to aqueous gels. Suitable red algae polysaccharides for use in the present invention are "Agar Agar 100" or "Agar Agar 150" from TIC Gums (Belcamp, MD, USA) or from "Gumix International Inc." (Fort Lee, NJ, USA) Quot; agar agar flate (CTFA) " derived from various Gelidium plant species commercially available as Agar Agar K-100 " or a red algae of close relative affinity. A baby; &Quot; Sea Plaque " from FMC (Philadephia, PA, USA) Agarose commercially available as " Agarose Typr Ib " from Sigma-Aldrich Co. Ltd. (Poole, UK); " Gelcarin LA ", Seakem 3 / LCM " or " Viscarin As a condensate containing the lambda-, iota- and kappa-fractions, water extracts obtained from various sources with Gigartinaceae or Solieriaceae, commercially available as "XLV" Carrageenan known in the industry under the trademark CTFA), furcellaran, commercially available from Gum Technology Corporation (Tucson, Arizona, USA) and Continental Colloids Inc. (Chicago, IL, USA), or mixtures thereof. , The red alga polysaccharide for use herein is selected from agar, agarose, kappa-carrageenan and furcellan, or mixtures thereof.
[107] Glucomannan : Glucomannan is essentially a polysaccharide containing the linear backbone of glucose and mannose residues. Glucomannan has short geodes bound to the linear backbone, and the acetyl group is optionally present at the C-6 position of the sugar unit. Generally, acetyl groups are found to be one per six to twenty sugar units. Glucomannan or derivatives thereof suitable for use herein have a ratio of mannose to glucose of from about 0.2 to about 3. Preferred glucomannans for use herein are FMC (Philadelphia, PA, USA) under the tradename " Nutricol quot; konjac flour ", a common name for powder made by grinding tuberous root of Amorphophallus konjac plant (Old Testament), and a diacetylated konjac; or mixtures thereof.
[108] Galactomannan : Galactomannan is a polysaccharide for vegetable storage in the endosperm of many seeds of Leguminosae. The term " galactomannan " as used herein includes all polysaccharides composed of galactose and mannose residues. Galactomannan contains a linear skeleton of (1,4) -bonded β-D-mannopyranosyl units. In the ring, a separate galactopyranose residue is bound as a branch by the - (1,6) -glucosid bond. Suitable galactomannans for use herein are fenugreek gum; Lucern; clover; Locust bean gum known in the industry as carobin gum under the trade designation (CTFA) under the trade name " Seagul L " from FMC (Philadelphia, PA, USA); Tara gum available from StarlightProducts (Rouen, France) or Bunge Foods (Atlanta, GA, USA); "Burtonite V7E" from TIC Gums (Belcamp, MD, USA), "Jaguar C" from Rhone-Poulenc (Marietta, GA, USA) or "Supercol" from Aqualon , Guar gum derived from ground excrement of Cyamopsis tetragonolobus; Cassia gum, available from Starlight Products (Rouen, France), or mixtures thereof. Preferably, the galactomannan for use herein has an average of from 1 to about 5 mannosyl units substituted with (1,6) -bonded-aD-galactopyranosyl units and is selected from the group consisting of guar gum, Locust bean gum and cacao gum, or mixtures thereof.
[109] Fermenting polysaccharides or derivatives thereof : Fermenting polysaccharides are polysaccharides that are commercially produced by fermentation of microorganisms in a medium containing carbon and nitrogen sources, buffering agents, and trace elements. Fermenting polysaccharides suitable for use herein are commercially available from Kelco (San Diego, Calif., USA), a high molecular weight heteropolysaccharide scour produced by pure-culture fermentation of carbohydrates by Pseudomonas elodea, (CTFA ) Gellan gum known in the industry as gellan; For example, "Keltrol CG 1000 / BT / F / GM / RD / SF / T / TF" from Calgon (Pittsburgh, PA, USA) or "Kelzan" from Kelco Xanthan gum, known as xanthan gum in the industry under the trade name High Molecular Weight Heteropolysaccharide (CTFA), which is commercially available and produced by pure-culture fermentation of carbohydrates by Xanthomonas campestris; Natto gum; Pullulan; Rhamsan gum; Curdlan; succinoglycan; Welan sword; Dextran and its derivatives sold as " Sephadex G-25 " from Pharmacia Fine Chemicals (Piscataway, NJ, USA); And sclerotium gum marketed as "Amigel" by Alban Muller International (Montreil, France), or mixtures thereof. Preferred fermenting polysaccharides or derivatives thereof are selected from gellan gum and xanthan gum, or mixtures thereof. More preferably, the fermenting polysaccharide or its derivative is xanthan gum.
[110] Extracts of Marine Invertebrates: Polysaccharides isolated from marine invertebrates, specifically exoskeletons of such invertebrates, are composed primarily of N-acetyl-D-glucosamine residues. Examples of such polysaccharides suitable for use herein include chitosan such as " Marine Dew " from Ajinomoto (Teakneck, NJ, USA); And hydroxypropylchitosan, such as " HPCH Liquid " and derivatives thereof, available from Ichimaru Pharcos (Yamagata Gun Gifu-Pref, Japan); Or a mixture thereof.
[111] Starch or derivative thereof : Starch is a polysaccharide composed of various ratios of two glucose polymers, amylose and amylopectin. Suitable materials for use herein include starches; Amylopectin; And dextrins and derivatives commercially available as "Nadex 360" from National Starch (Bridgewater, NJ, USA); Or mixtures thereof.
[112] Natural fruit extracts : Examples of natural fruit extracts suitable for use herein include pectin; And Arabian; Or mixtures thereof.
[113] Plant Fiber Derivatives : An example of a plant fiber extract suitable for use herein is cellulose.
[114] Natural plant extrudates : Polysaccharides from natural plant extrudates suitable for use herein include Karaya gum, tragacanth gum, gum arabic, tamarind gum, and guti gum, or mixtures thereof.
[115] Synthetic Gum : Examples of suitable resin gums for use herein include celluloses obtained from the resinous secretions of the insect Laxifer (Tachardia lacca)); Damargam; Copal gum and rosin gum; Or mixtures thereof.
[116] Preferably, a single sheet-thin sheet-like device previously formed herein contains a mixture of water-soluble polymeric gel-forming agents. The mixture comprises at least one nonionic water soluble polymer; At least one acrylic acid-based polymer or derivative thereof; One or more polysaccharides; And mixtures thereof. For example, a preferred water soluble polymeric gel former mixture herein may contain polysaccharides and nonionic water soluble polymers, or alternatively may contain two polysaccharides. More preferably, the water-soluble polymeric gel former is a polysaccharide mixture comprising (1) at least one red alga polysaccharide; Brown algal polysaccharide; Or mixtures thereof; And (2) one or more fermenting polysaccharides; Galactomannan; Glucomannan; Natural plant extrudate; Or natural fruit extract; And derivatives or mixtures thereof. More preferably, the water soluble polymeric gel formers of the device of the present invention comprise (1) at least one red alga polysaccharide; And (2) one or more fermenting polysaccharides; Glucomannan; Or galactomannan; And derivatives or mixtures thereof.
[117] In a preferred embodiment, the water soluble polymeric gel former of the present invention is a mixture of red alga polysaccharides and polysaccharides containing glucan mannan or galactomannan. Without wishing to be bound by theory, such incorporation of glucosamine or galactomannan in such polysaccharide mixtures complements the red alga polysaccharide and confers mechanical stiffness of the preformed single lamina sheet type device of the present invention. Moreover, in view of the improved mechanical properties and preferably low level of dehydration from a preformed single sheet metal sheet device, the ratio of red alga polysaccharide to glucomannan or galactomannan in the polysaccharide mixture may range from about 20: 1 to about 1: : 5, more preferably from about 5: 1 to about 1: 2.
[118] When the polymeric gel formers are natural, all of the above gels are under some degree of suspension development as defined above. The syneresis provides a mechanism for delivery of beneficial agents to the target area. On the surface of the adhesive gel, the slurry liquid layer is immediately available for diffusion, allowing the wear time of the device to be shortened. The preformed single lamina sheet type device of the present invention exhibits reasonably low levels of fluid migration, preferably the device of the present invention is moist. Excessive transaction causes the product to be ineffective and unattractive.
[119] The present inventors have also found that in order to obtain a polysaccharide gel with reasonable mechanical properties of rigidity and flexibility when the polysaccharide polymeric gel former selected for stiffness is mixed with a drug that imparts a plasticizing effect, The total concentration of the polymeric gel forming agent should be kept as low as possible. The low total concentration of the polysaccharides reduces the open gel structure so that other components of the original gel are not tightly bound in the gel network, allowing diffusion to be freely available.
[120] The preformed single lamina sheet type device of the present invention preferably exhibits a low level of fluid migration, and the device of the present invention is moist. As mentioned above, devices containing gels are always subject to slight dehydration, but excess syneresis results in products that are ineffective and unattractive.
[121] water
[122] In a preferred embodiment of the present invention wherein the one or more polymeric gel formers are water soluble, the preformed single lamina sheet type device of the present invention contains water. If present, the preformed single lamina sheet type device of the present invention has a total water content of from about 20% to about 99.5%, preferably from about 30% to about 95%, more preferably from about 40% % To about 85% by weight.
[123] gas
[124] The preformed single lamina sheet type device of the present invention is self supporting and does not require support or reinforcement by an occlusive or non-occlusive backing material, often referred to as a gas. However, if present, the gas can be combined with a single sheet metal sheet device and provide additional support or reinforcement. Preferably, the gas is non-clogged. In addition, the gas is particularly useful when the device according to the invention has a large surface area. If the gas is used for further support or reinforcement, the gas must be sufficiently compatible with them so as not to peel off from the device of the present invention.
[125] A wide variety of materials can be used as the gas. The following features are reasonable: (i) sufficient wet rigidity for application; (ii) sufficient resilience; (iii) sufficient loft and porosity; (iv) sufficient hydrophilic properties to allow the gel mixture to diffuse and penetrate into the gas. , (v) sufficient compatibility with the mixture, (vi) sufficient transparency or translucency, and (vii) suitable size.
[126] Alternatively, the gas may be used as a textured surface. When gas is used as the tissue surface, the gas is preferably easily peeled from the device.
[127] Examples of suitable gases suitable for one or more of the above items and useful herein include woven and nonwoven materials; A polymeric sheet material such as a formed film; And a paper gas.
[128] Beneficial agent
[129] As a major component of the present invention, the preformed single lamina sheet type device of the present invention contains one or more beneficial agents in a safe effective amount. The term " beneficial agent " as used herein means an active ingredient which provides a cosmetic and / or therapeutic effect in the field of application. The above definitions of benefit agents include, for example, vitamins, and wetting agents as well as the categories presented below.
[130] As used herein, the term " safe effective amount " refers to any amount that is sufficiently high to modify the condition to be treated or to deliver the effect to the desired skin, hair or nail, but is low enough to avoid serious side effects, Means the amount of beneficial agent of a reasonable effect. Whether a safe effective amount depends on the specific medicament, the ability of the medicament to penetrate through the skin or hair and / or nail, or to the daily life, the age of the user, the health condition of the user, the condition of the user's skin, hair or nail, It depends on factors.
[131] The term " pharmaceutically acceptable salts " includes any and all pharmaceutically acceptable salts suitable for contact with human tissues without undue toxicity, irritation, incompatibility, instability, irritation, ≪ / RTI >
[132] Generally, the preformed single lamina sheet type device of the present invention comprises from about 0.01% to about 60%, preferably from about 0.05% to about 30%, by weight of the at least one beneficial agent or mixture thereof, About 0.1% to about 20% by weight of the composition.
[133] The beneficial agents useful herein can be distinguished by their cosmetic or therapeutic effect or their required mode of action. It is understood, however, that the beneficial agents useful herein may provide a cosmetic or therapeutic effect in some cases or act through one or more aspects. Thus, the classifications herein are for convenience only, and the benefit agent is not limited to a particular application or presented application. The following benefits are useful in the preformed single lamina sheet type device of the present invention.
[134] Anti-inflammatory agents : Anti- inflammatory agents may be effective in treating and inhibiting chronic disorders of acne vulgaris, pilosebaceous follicles. Such conditions include inflammation of the follicular branchal organs causing damage including papules, pustules, cysts, comedones, and severe scars. The bacterial Corynebacterium acne and Staphylo-coccus epidermis are generally present as peripermal inclusions. Examples of useful surfactants include keratolytic as disclosed in WO98 / 18444 incorporated herein by reference. Additional useful active agents include latinoids such as the latino acids (e.g., cis and / or trans) and derivatives thereof (e.g., esters); Retinol and its ester derivatives (e.g., retinyl propionate, retinyl acetate); Adabel acid, adalphalene, tazarotene, allantoin, aloe extract, arbietate and its salts, ASEBIOL (Laboratories Serobiologiques, Somerville, NJ), azaleic acid, , Bisporenol, bisquinolones, benzoquinolines, benzoyl peroxides, berberine, BIODERMINE (Sederma, Brooklyn, NY), class bioflavonoids, bisabolol, , s-carboxymethyl cysteine, carrot extract, cassin oil, clove extract, citral, citronellal, climazole, COMPLETECH MBAC-OS (Lipo, Paterson , NJ), CREMOGEN M82 (Dragoco, Totowa, NJ), cucumber extract, dihydroacetic acid and its salts, dehydroepiandrosterone and its sulfate derivatives, dichlorophenylimidazole dioxalane, d, l - valine and its esters, DMDM hydantoin, erythromycin, escinol, ethylhexyl monoglyceryl ether, ethyl 2-hydroxy undecanoate, farnesol, farnesyl acetate, geraniol ), Geranyl geraniol, glabridin, gluconic acid, gluconolactone, glyceryl monocaprate, glycolic acid, grape seed extract, gugu lipid, HEDERAGENIN (Maruzen, Morristown, Hecoritin, hinokitol, Hobbes extract, hydrogenated rosin, 10 hydroxydecanoic acid, ichthyol, interleukin 1 alpha antagonist, KAPILARINE (Greentech, Saint Beauzire France), ketocona-zole ), Lactic acid, lemon grass oil, LOCHOCHALCONE LR15 (Maruzen, Morristown, NJ), linoleic acid, LIPACIDE C8CO (Seppic, Paris, France), lovastatin, 4 methoxysalicylic acid, metronidazole, minocycline minocycline, muk nocin and its ester, nisin, panthenol, 1-pentadecanol, peonia extract, peppermint extract, phelladendron extract, 2-phenyl-benzothiophene derivatives, phloretin, PHLOROGINE (Secma, Pontrieux, France), phosphatidylcholine, proteinase, quercetin, chitosan extract, rosemary extract, The extracts of rutin, sage extract, salicin, salicylic acid, serine, skull cap extract, siber hegner extract, siberian saxifrage extract, silicol, SURFATE, Sodium Sulfoacetamide, SOPHORA EXTRACT (Maruzen, Morristown, NJ), Sorbic Acid, Sulfur, Sunder Vati Extract, Tea Tree Oil, Tetrahydroabietic Acid, Threonine, Thyme Extract , Tioxolone, tocopherol 3-trideceno-2-ol, triclo-san, tropolone, UNITRIENOL T27 (Unichem, Chicago, IL), vitamin D3 and The present invention relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament for the treatment and / or prevention of an inflammatory disease, the analog, the white thyme oil, the willow bark extract, the wogonin, the ylang ylang maleate, Zwitterionic surfactants (e.g., cetyldimethylbetaine), and mixtures thereof.
[135] Softener: include the following Examples of useful softening agents herein are: mineral oil, mineral oils (petrolatum), C ₇ -C ₄₀ branched chain hydrocarbons, C ₁ -C ₃₀ carboxylic acid of the C ₁ -C ₃₀ alcohol esters, C ₂ -C ₃₀ dicarboxylic acid, the C ₁ -C ₃₀ alcohol esters, C ₁ -C ₃₀ carboxylic acid monoglyceride, C ₁ -C ₃₀ carboxylic acid of the diglycerides, triglycerides of C ₁ -C ₃₀ carboxylic acids , C ₁ -C ₃₀ carboxylic acid of ethylene glycol monoesters, C ₁ -C ₃₀ carboxylic acid esters of ethylene glycol, C ₁ -C ₃₀ carboxylic acids, propylene glycol monoesters, C ₁ -C ₃₀ carboxylic For example, propylene glycol diesters of acids, C ₁ -C ₃₀ carboxylic acid monoesters and polyesters of sugars such as sefa cottonate (sucrose polyketoneside), polydialkylsiloxanes, polydialyls Siloxane, polyalkarylsiloxane, silane having 3 to 9 silicon atoms Romero dimethicone, vegetable oils, hydrogenated vegetable oils, polypropylene glycol C ₄ -C ₂₀ alkyl ethers, di-C ₈ -C ₃₀ alkyl ethers, and mixtures thereof. These agents are disclosed in more detail in WO98 / 18444 incorporated herein by reference.
[136] Non-steroidal anti-inflammatory actives (NSAIDS) : Examples of suitable NSAIDS and esters for use herein are disclosed in WO98 / 18444 incorporated herein by reference. Non-limiting examples of additional non-steroidal anti-inflammatory drugs (NSAIDS) include: flufenamic acid; Panthenol and its ethers and ester derivatives, for example, panthenol ethyl ether, panthenyl triacetate; Pantothenic acid and salts and ester derivatives thereof, especially calcium pantothenate; Aloe vera, bisabolol, allantoin and glycyrrhizic acid, glycyrrhizic acid, and derivatives thereof, such as ammonium glycinate salts such as ammonium glycitylate and esters such as stearyl glycyrrhetinate (Plant genus / Glycyrrhiza glabra). ≪ / RTI >
[137] Local Anesthetics : Examples of suitable topical anesthetics for use herein are benzocaine and bupivacaine. Additional suitable examples are disclosed in WO98 / 18444 incorporated herein by reference.
[138] Tanning Agents and Accelerators : Artificial tanning agents can help to increase skin melanin or mimic natural tanning by producing increased melanin appearance on the skin. Non-limiting examples of artificial tanning agents and accelerators include: Glucosyl tyrosinate and acetyl tyrosine, brazilin, caffeine, coffee extract, DNA segment, isobutyl methyl xanthine, methyl xanthine, PHOTOTAN Laborato-ires Serobiologiques, Somerville, NJ), prostaglandin, tea extract, theophylline, UNIPERTAN P2002 and UNIPERTAN P27 (Unichem, Chicago, IL); And mixtures thereof. Additional artificial tanning agents useful herein are disclosed in WO98 / 18444 which is incorporated herein by reference.
[139] Preservatives: Examples of suitable preservatives for use herein include alcohols, benzoates, sorbic acid, and mixtures thereof.
[140] Antimicrobial and antimicrobial active agents : Antimicrobial and antimicrobial active agents may be effective in inhibiting the growth and growth of bacteria and fungi. Non-limiting examples of antimicrobial and antimicrobial active agents include: ketoconazole, ciclopirox, benzoyl peroxide, tetracycline, azelaic acid and its derivatives, ethyl acetate, Aniline, arnica extract (helenalin acetate and 11, 13 dihydroxyacetone), alantolactone, isolectolactone, alkanet extract (alaninin), anise, Aspirin extracts (phloro, lucinol-containing extracts), horseradish extract (berberine chloride), bay sweet extract, bayberry Bark extracts such as bark extract (myricitrin), benzalkonium chloride, benzethonium chloride, benzoic acid and its salts, benzoin, benzyl alcohol, bressilla thistle, bletilla tuber ), Blood But are not limited to, bloodroot, bois de rose oil, burdock, butylparaben, cade oil, CAE (Ajinomoto, Teaneck, NJ), cajeput oil, cangzhu, Caraway oil, caskarilla shell (marketed under the trademark ESSENTIAL OIL), cedarleaf oil, chamomille, chaparral, chlorophenesin, Citricella oil, clove oil, dihydroacetic acid and salts thereof, dill seed oil, DOWICIL 200 (Dow Chemical Co., Midland, Mich.), Echinacea echinacea, elenolic acid, epimedium, ethyl paraben, FO-TI, galbanum, garden burnet, GERMALL 115 and GERMALL II (ISP-Sutton Labs, Wayne Giant knotweed, GLYDANT and GLYDANT PLUS (Lonza, Fairlawn, NJ), grape seed oil, Hexamidine diisethionate, hinokitiol, honey, hinoki, hops, immortelle, iodopropynyl butylcarbamide (Lonza, Fairlawn, NJ), iso Butylparaben, isopropylparaben, JM ACTICARE (Microbial Systems International, Nottingham, UK), juniper berries, KATHON CG (Rohm and Haas, Philadelphia, PA, USA), labdanum, lavender, Lemon balm oil, Lemon grass, Methyl paraben, Mint, Mustard, Myrrh, Seed oil, Orthophenyl phenol, OLIVE LEAF EXTRACT (Bio Botanica, Hauppauge, NY), Parsley, patchouli oil, peony root, PHENONIP (Nipa Labs, Wilmington, DE), phytosphingo-sine, sole oil, PLANSERVATIVE (Campo Research, Raffles Quay, Singa-pore), propylparaben, Quillaira, rhubarb, rose geranium oil, rosemary, sage, Sulphonic acid, sisafras, savory, sichuan lovage, sodium metabisulfite, sodium sulfite, SOPHOLIANCE (Soliance, Compiegne, France), sorbic acid and its salts, But are not limited to, sphingosine, stevia, storax, tannic acid, tea, tea oil (cassey oil), thyme, triclosan, triclocarban, tropolone, (turpentine), umbelliferone (antibacterial), and yucca, or mixtures thereof. Additional examples of antimicrobial and antimicrobial activators useful herein are disclosed in WO98 / 18444, which is incorporated herein by reference.
[141] Skin Tranquilizers: Skin tranquilizers can be effective in suppressing or treating inflammation of the skin. A sedative improves the appearance of the skin, which is an advantage of the present invention, for example, the medicament contributes to a more uniform, acceptable skin tone or color. Non-limiting examples of skin depressants include: absinthium, acacia, aescin, alder buckthorn extract, allantoin, aloe, APT (Centerchem, Stanford, CT) Astragalus, Astragalus root extract, azulene, BAICALIN SR 15 (Barnet Products Dist., Englewood, NJ), baikal skullcap, baizhu, (balsam canada), bee pollen, BIOPHYTEX (Laboratories Serobiologiques, Somerville, NJ), bisabolol, cohosh, black cohosh extract, blue cohosh, blue cohosh extract, boneset, borage, glass frit oil, glass lard seed oil, bromelain, calendula, calendula extract, CANADIAN WILLOWBARK EXTRACT (Fytokem), candelilla wax, Cangzhu, canola phytosterol, The present invention relates to a composition comprising at least one compound selected from the group consisting of capsicum, carboxy peptidase, celery seed, celery extract, CENTAURIUM (Sederma, Brooklyn, NY), centaury extract, chamazulene, Extracts, chaparral, chaste tree, chestnut extract, chickweed, chicory root, chicory root extract, chirata, chishao, colloidal oatmeal, (DEA), dearian angelica, DEVIL'S CLAW (MMP Plainfield, NJ), divalent metals (magnesium, calcium, magnesium, (Pentapharm, Basel, Switzerland), Eleuthero, ELHIBIN (Pentapharm, Basel, Switzerland), ENTELINE 2 (Secma, Inc.), etc.), doggrass, dogwood, EASHAVE , Pontrieux, France), ephedra, epimedium, Fungfeng, ficin, forsythia fruit, ganoderma (fruit), fescue, fescue, fescue, fescue, esculoside, evening primrose, ganoderma, gaoben, GATULINE A (Gattefo-sse, Saint Priest, France), gentian, germanium extract, gingko bilboa, ginkgo biloba, ginseng extract, goldenseal ), Gorgonian extract, gotu kola, grape fruit extract, guaiac wood oil, guggal extract, helenalin ester, henna, Horehound extract, hose chess nut, hinch, huzhang, hypericum, ichthyol, immor-telle, ipecac, yulmu, jujube, Kola extract, LANACHRYS 28 (Lana Tech, Paris, France), lemon oil, lianqiao, licorice root, Such as ligusticum, ligustrum, lavage root, luffa, mace, magnolia flower, manjistha extract, margaspidin, matricin, MICROAT IRC (Nurture, Missoula, MT) Mint, mistletoe, MODULENE (Seporga, Sophia Antipolis, France), mung bean extract, musk, oatmeal extract, orange, panthenol, (Biofabrica, Hauppauge, NY), PREREGEN (Pentapharm, Basel, Switzerland), Pepper, QUENCH T (Centerchem, Stamford, CT), quillaia, papain, peony peel, peony root, PHYTOPLENOLIN Red salvia, rehmannia, rhubarb, rosemary, rosmarinic acid, royal jelly, rue, rutin, sandalwood, sanqi, sarsaparilla, , Saw palmetto, SENSILINE (Silab, Brive, France), SIEGESBECKIA (Sederma, Brooklyn, NY), stearyl glycyrrhetinate (gl ycyrrhetinate, STIMUTEX (Pentapharm, Basel, Switzerland), storax, sweet birch oil, sweet woodruff, tagete, tea extract, thyme extract, , Tocopherol, tocopheryl acetate, triclosan, turmeric, urimei, ursolic acid, Baitsong shell, witch hazel, xinyi, yarrow, , Yeast extract, yucca, and mixtures thereof.
[142] Sunscreens : Examples of suitable sunscreen agents useful herein are disclosed in WO98 / 18444, which is incorporated herein by reference. Additional examples of sunscreen agents useful herein include diethanolamine p-methoxy cinnamate, dioxybenzone, ethyl dihydroxypropyl PABA, glyceryl aminobenzoate, lawsome, and dihydroxyacetone Menthyl anthranilate, methyl anthranilate, octyldimethyl PABA, red oil, sulisobenzone, triethanolamine salicylate, and mixtures thereof.
[143] Skin Barrier Recovery Aid : The skin barrier repair activator is a skin care active that can help restore and replenish the natural moisture barrier function of the epidermis. Non-limiting examples of skin barrier repair adjuvants include: brassicasterol, caffeine, campestelol, canola-induced sterol, CERAMAX (Quest, Ashford, England), CERAMIDE H03TM CERAMIDE II (CERAMIDE II) and CERAMIDE III (Quest, Ashford, England), CERAMIDE IIIB (Cosmoferm, Delft, Netherlands), CERAMIDE IS 3773 (Laboratories Serobiologiques, Somerville, NJ), CERAMINOL (Inocosm, Chatenay Cholesterol hydroxystearate, cholesterol isostearate, 7-dihydrocholesterol, DERMATEIN BRC and DERMATEIN GSL (Hormel, Inc., Austin, MN); ELDEW PS 301 (Ajinomoto, Teaneck, NJ), FITROBROSIDE (Pentapharm, Basel, Switzerland), GENEROL 122 (Henkel, Hoboken, NJ), glyceryl serinamide, Lactic acid, LACTOMIDE (Pentapharm, Bas Lanolin, lanolosterol, laurylglucamide laurate, lipoic acid, n-acetylcysteine, serine, n-acetyl-L-serine, n-methyl N-acetyl-L-serine, NET STEROL-ISO (Barnet Products, Englewood, NJ), niacinamide, nicotinic acid and its esters, nicotinyl alcohol, palmitic acid, panthenol, panthetine, phosphodiesterase inhibitors, PHYTO / CER (Intergen, Purchaser, NY), PHYTOGLYCOLIPID MILLET EXTRACT (Barnet Products Distributor, Englewood, NJ), PHYTOSPHINGOSINE (Gist Brocades, King of Prussia, PA), PSENDOFILAGGRIN (Brooks Industries, South Plainfield, NJ) , QUESTAMIDE H (Quest, Ashford, England), serine, stigmasterol, sitosterol, stigmastanol, soybean-derived sterols, sphingosine, s-lactylglutathione, stearic acid , SUPER STEROL ESTERS (Croda, Parsippany, NJ), thioctic acid TCE CERAMIDE OIL (Campo Research, Raffles Quay, Singapore), trimethylglycine, tocopheryl nicotinate, vitamin D3 and analogs or derivatives thereof, and Y2 (Ocean Pharmaceuticals), or mixtures thereof.
[144] Anti-wrinkle and anti-skin active agents : anti-wrinkle and anti-skin active agents may be effective in replenishing or restoring epidermis and / or skin layers. These actives generally provide a desirable skin care benefit by promoting or maintaining the natural process of epidermal detachment and / or by strengthening the skin matrix components (e.g., collagen and glycosaminoglycans). Non-limiting examples of anti-wrinkle and anti-skinning active agents include nicotinic acid and its esters, nicotinyl alcohol, estrogens and estrogen compounds, or mixtures thereof. Additional suitable examples of anti-wrinkle and anti-skinning active agents useful herein are disclosed in WO98 / 18444, which is incorporated herein by reference.
[145] Skin Recovery Agents : Skin Recovery Agents can be effective in restoring the epidermis and / or skin layer. Non-limiting examples of skin repair activators include: actein 27-deoxyactein cimicifugo-side (cimigoside), adapalene, Aminopropyl dihydrogen phosphate, AMADORINE (Barnet Products, Englewood, NJ), anise (anise), adenosine, adenosine, ) Ascorbic acid and its derivatives, ascorbyl palmitate, asiatic acid, ascorbic acid and its derivatives, AOSINE (Secma, Pontrieux, France), arginine aminobenzoate, ASC III (E. Merck, Darmstadt, Germany) Asialicoside, ARLAMOL GEO (ICI, Wilmington, DE), azelic acid, benzoic acid derivatives, bertholletia extract, betulinic acid, BIOCHANIN A, BIOPEPTIDE CL and BIOPEPTIDE EL , Brooklyn, NY), biotin, Rach strawberry peel extract, blackberry flower extract, black cohosh extract, blue cohosh extract, butanoyl betulinic acid, catechol-amine, chalcone, chestnut extract, (Barnet Products, Inc., Englewood, NJ), daidzein, Angelica japonica extract, Daruchi extract, Clove extract, Coenzyme Q10 (ubiquinone), coumestrol, CPC PEPTIDE But are not limited to, those selected from the group consisting of darutoside, dibromo laurinterol, 1-decanoyl-glycerophosphonic acid, dihydrocholesterol, dihydrodicresol, dehydrodieugenol, Dihydroxystearic acid and its derivatives, dihydroepiandrosterone sulfate, dianethole, 2,4-dihydroxybenzoic acid, diosgenin (dihydroxyacetic acid, diosgenin, disodium ascorbyl Esterilyl SH (Laboratories Serobiologiques, Somerville, NJ), ENDONUCLEINE (Laboratories Serobiologiques, Somerville, NJ), equol, ergosterol (available from Dow Chemical Company), EDELINE (Seporga, Sophia Antipolis, ergosterol), eriodictyol, estrogen and its derivatives, ethocyn, erythrobic acid, farnesol, farnesyl acetate, fennel extract, FIBRASTIL Flavobacterium (especially Sibutramycin, Sederma, Brooklyn, NY), FIBROSTMULINES S AND P (Sederma, Brooklyn, NY), FIRMOGEN IS 8445 (Laboratories Serobiologiques, Somerville, NJ) chalcone and chalcone such as monohydroxy and dihydroxychalcone), formononetin, Forsythia fruit extract, gallic acid ester, gamma aminobutyric acid, GATULINE RC (Gattle-fosse, Saint Priest, France), Zenith Ginsenoside, R 2 _O , R _6-1 , R _6-2 , ginsenoside, genistein, gentisyl alcohol, bilboa extract, ginseng extract, gentisyl alcohol, _6-3 R, R _C, R _D, R _E, R _F, R _F-2, R _{G-1, G-2} R, glucopyranosyl-1-ascorbate, glutathione and its esters, glycitein glycitein, eptyloxy 4 salicylic acid, hesperitin, hexahydrocucumin, hmg-coenzyme A reductase inhibitor, hops extract, 11 hydroxydecanoic acid, 10-hydroxydecanoic acid, 25-hydroxycholesterol, ISOFAVONE SG 10 (Barnet Products, Englewood, NJ), kinetin, L-2-oxo-thiazolidine-4-carboxylic acid ester, lactate di Lecithin, luteolin, lysophosphatidylcholine, lectin, LICHOCHAL- CONE LRI5 (Maruzen, Morristown, NJ), licorice extract, lipoic acid, lumisterol, luteolin, magnesium But are not limited to, ascorbyl phosphate, melatonin, melibiose, metalloproteinase inhibitors, metoprene, metoprenic acid, 4-methoxysalicylic acid, mevalonic acid, MPC COMPLEX , Berlin, Germany), N-acetylcysteine, N-methylserine, N-methyltaurine, N, N'-bis (lactyl) cysteamine, naringenin, neotigo-genin, - octanoyl salicylic acid, 0-desmethyllangoenesin, oleanolic acid, pantethine, phenylalanine, photoanethone, phytic acid and its salts, (S) selected from the group consisting of peridin, placental extract, pratensein, pregnenolone, pregrenolone acetate, pregrenolon succinate, premarin, quillaic acid, raloxifene ), REPAIR FACTOR 1 (Sederma, Brooklyn, NY), REPAIR FACTOR SPC (Sederma, Brooklyn, NY), Retinal, Eight (C ₂ -C ₂₀ ester of the alcohol), retinol, retinyl acetate, retinyl glue Kuno oleate, retinyl linoleate, retinyl palmitate, retinyl propionate, REVITALIN BT (Pentapharm Inc., Basel, Switzerland) , s-carboxymethyl cysteine, salicylic acid, SEANAMINE FP (Laboratories Serobiologiques, Somerville, NJ), sodium ascorbyl phosphate, soya extract, spleen extract, tachysterol, taurine, (Eg, tazarotene, thymu-len, thymus extract, thyroid hormone, tigogenin, tocopherylretinoate, toxifolin, transretinoic acid, traumatic acid Vitamin K, vitex extract, yam extract, yamogenin, and zitin, and the like, as well as the antioxidants and antioxidants, such as tricolin citrate, triphoside, uracil derivatives, ursolic acid, vitamin D ₃ and its analogs, vitamin K, vitex extract, zeatin, or a mixture thereof.
[146] Lipid: Examples of suitable lipids are cetyl ricinoleate (ricinoleate), cholesterol-hydroxy-stearate, cholesterol isostearate, CREMEROL (Amerchol Corporation, Edison, NJ), ELDEW C1301 (Ajinomoto Inc., Teaneck, NJ), lanolin, MODULAN (Amerchol, Edison, NJ), OHLAN (Amerchol, Edison, NJ), petrolatum, phytantriol, and SUPER STEROL ESTER (Croda, Parsippany, NJ) do.
[147] Skin Whitening Agents : Skin lightening agents can substantially reduce the amount of melanin in the skin or provide this effect with other mechanisms. Skin lightening agents suitable for use herein are disclosed in EP-A-758,882 and EP-A-748,307, both of which are incorporated herein by reference. Additional examples of skin lightening agents include: adapalene, aloe extract, aminotyrosine, ammonium lactate, anethole derivatives, apple extract, arbutin, ascorbic acid and its derivatives, asbestos Berry extract, burberry extract, BURNET POWDER (Barnet Products, Inc., Englewood, NJ), bovine leaf extract, corn palmitate, azelaic acid, bamboo extract, bearberry extract, bletilla tuber, bupleurum falcatum extract, ), Butylhydroxyanisole, butylhydroxytoluene, chuanxiong, dang-gui, deoxyarbutine, 1,3-diphenylpropane derivatives, 2,5 dihydroxybenzoic acid and Derivatives such as 2- (4-acetoxyphenyl) -1,3-ditane, 2- (4-hydroxyphenyl) -1,3-ditane, ellagic acid, escinol, Estragole derivatives, esculoside, esculetin, FADEOUT (Pentapharm (Gattefosse, Saint Priest, France), geranic acid and derivatives thereof, geranyl alcohol, glycerol and its derivatives, ganoderma extract, gabapentin, , Glabridin and its derivatives, glucopyranosyl-1-ascorbic acid, gluconic acid, glucosamine, glycolic acid, glycyrrhizinic acid, green tea extract, 4-hydroxy-5-methyl- ] - furanone, hydroquinine, 4-hydroxyanisole and derivatives thereof, 4-hydroxybenzoic acid derivatives, hydroxycaprylic acid, inositol ascorbic acid, kojic acid, (Pentapharm, Basel, Switzerland), Morus alba (Lactobacillus sp.), Lycorice P-TH (Barnet Products, Englewood, NJ), linoleic acid, magnesium ascorbyl phosphate, MELFADE Morus alba extract, mulberry root extract, niacinamide, Tannic acid and its esters, nicotinyl alcohol, 5-octanoyl salicylic acid, parsley extract, phellinus linteus extract, placenta extract, pyrogallol derivative, retinoic acid, retinol, 4 Resorcinol Derivatives, 3,5 Resorcinol Derivatives, Rose Fruit Extract, Lucinol, Salicylic Acid, Pine Pomace Extract, SOPHORA (Acetate, Propionate, Palmitate, Linoleate) Thioresorein, 3,4,5 trihydroxybenzyl derivatives, tranexamic acid, TYROSLAT 10, 11 (Fytokem), vitamin D3 and its derivatives, Analogs, yeast extracts, or mixtures thereof.
[148] Antiperspirants : Antiperspirants can reduce sebum production in sebum glands. Examples of suitable antiadhesive agents include: aluminum hydroxychloride, ASEBIOL (Laboratories Serobiologiques, Somerville, NJ), BIODERMINE (Sederma, Brooklyn, NY), climbazole, COMPLETECH MBAC-0S , Peterson, NJ), corticosteroids, cucumber extracts, dihydroacetic acid and its salts, dichlorophenylimidazole dioxalane, ketoconazole, LICHOCHALCONE LR 15 (Maruzen), niacinamide, nicotinic acid and its esters, S-carboxyl methyl cysteine, SEPICONTROL AS, spironolactone, tioxolone, tocopherol, UNITRIENOL T27 (Unichem, Inc.), pyrrolidine, Chicago IL), and ZINCIDONE (UCIB, Inc., Clifton, NJ), or mixtures thereof.
[149] Fiji Stimulants : Fiji stimulation lines can increase sebum production by sebaceous glands. Examples of unconjugated sebum stimulants include bryonolic acid, COMPLETECH MBAC-DS (Lipo, Paterson, NJ), dihydroepiandrosterone (also known as DHEA), orizanol, and mixtures thereof .
[150] Skin Sensate : Non-limiting examples of suitable skin senses for use herein include: camphor, thymol, 1-menthol and its derivatives, eucalyptus, A reagent that imparts a cold feeling like carboxamide; Menthylene ether and menthene ester; And a method for producing the same, comprising the steps of: mixing a mixture comprising a mixture of a sweetener and a sweetener selected from the group consisting of pepper tincture, pepper extract, pepper powder, vanillylamide nonanoate, nicotinic acid derivatives (benzylnicotinate, methylnicotinate, phenylnicotinate etc.), capsaicin, Nasturtium officinale extract, Zanthoxylum piperitum extract and ginger extract, or mixtures thereof.
[151] Protease Inhibitors : Protease inhibitors are compounds that inhibit the proteolytic process, that is, the cleavage of a protein into smaller peptide fractions or amino acids. Examples of suitable protease inhibitors include AE COMPLEX (Barnet Products, Englewood, NJ), ALE (Laboratoires Seporgia, Sophia Antipolis, France), allicin, AOSAINE (Secma Biotechnologies Marine, Pontrieux, France), APROTININ (Pentapharm AG, Basel, Switzerland), Areca catechu extract, BLUE ALGAE EXTRACT (Collaborative Labs Inc., East Setauket, NY), CENTAURIUM (Sederma, Brooklyn, DISACOSIDE HF 60 (Barnet Products, Englewood, NJ), ELHIBIN (Pentapharm AG, Basel, Switzerland), FLUID OUT COLLOID (Vegetech), DERMOPROTECTINE (Sederma, Brooklyn, NY) INCYTE HEATHER (Collaborative Labs Inc., East Setauket, NY), MICROMEROL (Collaborative Labs Inc., East Setauket, NY), HYPOTAURINE (Sogo Pharmaceutical Co. Ltd., Chiroda- NY), PEFABLOC SP (Pentapharm AG, Basel, Switzerland), SEPICONTROL AS (Seppic, Paris, France), SIEGE SBECKIA (Sederma, Brooklyn, NY), SOPHORINE and THIOTAINE (Barnet Products, Englewood, NJ), and mixtures thereof.
[152] Skin swelling agents: Examples of skin swelling agents are BIOCARE SA (Amerchol Corporation, Edison, NJ), egg albumin, FLEXAN 130 (National Starch Company, Bridgewater, NJ), GATULINE LIFTING (Gattefosse Corporation, Saint Priest, France), PENTACARE HP (Pentapharm AG, Basel, Switzerland), VEGESERYL (Laboratories Serbioloques, Somerville, NJ), and mixtures thereof.
[153] Itch prevention components: Examples of itch prevention constituents are STIMU-TEX (Pentapharm AG Company, Basel, Switzerland), TAKANAL ( Ikeda-Distributor, Tokyo, Japan), ICHTHYOL (International Sourcing-Distributor Inc., Upper Saddle River, NJ) , OXYGENATED GLYCERYL TRIESTER (Laboratoires Seporgia, Sophia Antipolis, France) and mixtures thereof.
[154] Hair growth inhibitors : Examples of suitable agents for inhibiting hair growth include 17 beta-estradiol, adamantiguanidine, adamantylamidine, adenylosuccinate synthase inhibitors, angiogenic steroids, aspartate But are not limited to, transcarbamylase inhibitors, betamethasone valerate, bisapolol, copper ions, turmeric extract, cyclooxygenase inhibitors, cysterne pathway inhibitors, dehydroacetic acid, dehydroepiandrosterol, diopyroses, KAPILANNE (International Sourcing Distributor), KAPILANNE (International Sourcing Distributor), KAPILANNE (KAPILANNE, KAPILANNE, KAPILANNE, KAPILANNE, KAPILANNE) , Upper Saddle River, NJ), L-5-diaminopentanoic acid, L-asparagine synthase inhibition , Linoleic acid, lipoxygenase inhibitors, longa extract, mimosinamine dihydrochloride, mimosin, nitric oxide synthase inhibitors, nonsteroidal anti-inflammatory agents, ornithine decarboxylase inhibitors, ornithine aminotransferase Phytoestrone, phosphodiesterase inhibitor, pleione extract, protein kinase C inhibitor, 5-alpha reductase inhibitor, sulfhydral active compound, thioxolone, conversion Growth factor beta 1, urea, zinc ions, and mixtures thereof.
[155] Examples of 5-alpha reductase inhibitors : 5-alpha reductase inhibitors include CLOVE 55 (Barnet Products Distributor, Englewood, NJ), ethinyl estradiol, genistein, genistein, Licochalcone LR-15, Saw palmetto extract, SOPHORA EXTRACT (sold by Maruzen, Morristown, NJ), ZINCIDONE (sold by UCIB, Clifton, NJ), and mixtures thereof.
[156] Desquamation enzyme enhancers : These agents enhance the activity of endogenous epidermal release enzymes. Non-limiting examples of epidermal release enzyme enhancers include N-methyl serine, serine, trimethyl glycine, and mixtures thereof.
[157] Anti-glycation Agents: Anti-glycation agents prevent sugar-induced cross-linking of collagen. A suitable example of an agonist agonist includes AMADORINE (Barnet Products Distributor, Englewood, NJ).
[158] Preferred examples of useful beneficial agents herein include ascorbic acid and its derivatives, salicylic acid, niacinamide, tocopheryl nicotinate, benzoyl peroxide, 3-hydroxybenzoic acid, flavonoids (e.g., flavanone, chalcone), parnesol farnesol, 2-hydroxycaproic acid, 2-hydroxyhexanoic acid, cis-retinoic acid, trans-retinol, Cysteine, lipoic acid, tocopherol and its esters (e. G., Tocopheryl acetate), azelaic acid, arachidonic acid, tetracycline < RTI ID = 0.0 > But are not limited to, corticosteroids, corticosteroids, corticosteroids, corticosteroids, corticosteroids, corticosteroids, corticosteroids, corticosteroids, 3, 4'-trichloro - include those selected from carboxylic banil lead, loam rocks blood (octopirox), lidocaine hydrochloride, clotrimazole, miconazole, ketoconazole, neo myth sulfate, theophylline, and the group consisting of a mixture thereof.
[159] For cosmetic treatment methods of the skin, hair or nail, the cosmetic benefit agent is selected from the group consisting of anti-wrinkle and anti-skin active agents, anti-acne active agents, artificial tanning and accelerating agents, skin softening agents, wetting agents, , A skin whitening agent, a skin sensation agent, a skin sedative agent, a lipid, an anti-fatigue agent, an anti-irritant, a sunscreen agent, a protease inhibitor, a skin swelling agent, an itch inhibiting component, and a epidermal releasing enzyme enhancer, or a mixture thereof.
[160] Wetting agent
[161] A preferred preformed single sheet thin sheet type device comprises at least one wetting agent. The wetting agent can be added to achieve the plasticizing effect and, when applied to the target surface, can increase the moisturizing properties of a preformed single sheet metal sheet device. In addition, certain humectants, such as hexylene glycol, can contribute to the antimicrobial properties and properties of the preformed single lamina sheet type device of the present invention. Further, although not limited by the theory of the present invention, introducing a wetting agent into the preformed single lamina sheet type device of the present invention increases the stability of the device to such an extent that less degradation occurs under extreme temperature conditions. Generally, the preformed single lamina sheet type device of the present invention comprises from about 1.0 wt% to about 45 wt%, preferably from about 5 wt% to about 40 wt%, more preferably from 10 wt% to about 30 wt% Wetting agents.
[162] Wetting agents suitable for use in the present invention are described in WO98 / 22085, WO98 / 18444 and WO97 / 01326, both of which are incorporated herein by reference. More suitable wetting agents include amino acids and their derivatives (e.g., proline and arginine aspartate), 1,3-butylene glycol, propylene glycol and water and codium tomentosum extract, collagen amino acids or peptides, Glycerin, glycerol monopropoxylate, glycogen, hexyleneglycol, molasses and glycerol, glycerin, glycerin, glycerin, glycerin, glycerin, glycerin, glycerol, Hydroxysterose mucopolysaccharide, inositol, keratin amino acid, LAREX A-200 (available from Larex), glycosaminoglycan, methoxy PEG 10, methylglucoside-10 and 20 (Both commercially available from Amerchol, Edison, NJ), methyl glucose, 3-methyl-1,3-butanediol, N-acetylglucosamine salt, panthenol, polyethylene glycol PEG 6, PEG 8, PEG 9), pentaerythritol, 1,2-pentanediol, PPG-1 glyceryl ether, PPG-1 glyceryl ether, and derivatives thereof (e.g., PEG 15 butanediol, PEG 4, PEG 5 pentaerythritol, 9, 2-pyrrolidone-5-carboxylic acid and salts thereof such as glyceryl PCA, saccharide isomeride, SEACARE (available from Secma), sericin, silk amino acid, sodium acetyl hyaluronate, Sorbitol 20, sorbets 6, sugars and sugar alcohols and derivatives thereof (e.g., glucose, mannose and polyglycerol sorbitol), trehalose, triglycerol, trimethyolpropane , Tris (hydroxymethyl) aminomethane salt, and yeast extract, or mixtures thereof.
[163] The wetting agent used herein is preferably selected from glycerin, butylene glycol, hexylene glycol, panthenol and polyethylene glycol and derivatives thereof, or mixtures thereof.
[164] Emulsifying agent / surfactant
[165] In addition, the preformed single lamina sheet type device of the present invention may optionally comprise one or more surfactants and / or emulsifiers. The emulsifiers and / or surfactants generally aid in dispersing and suspending the non-emulsified phase in the continuous phase. Surfactants are also useful when the product is for skin, hair or nail cleansing purposes. For convenience, the emulsifying agent is referred to as the term " surfactant ", so that the term " surfactant (s) " refers to those surfactants that, when used as emulsifying agents, such as skin, hair or nail cleansing, Used to refer to. Known or conventional surfactants can be used in the compositions provided that the selected agents are chemically and physically compatible with the essential components of the composition and provide the desired properties. Suitable surfactants include silicone materials, non-silicone materials, and mixtures thereof.
[166] The compositions of the present invention preferably comprise from about 0.01% to about 15% of a surfactant or mixture of surfactants. The exact surfactant or mixture of surfactants will depend on the pH of the composition and other compositions present. Preferred surfactants are nonionic.
[167] Nonionic surfactants useful herein are condensation products of fatty acids and alkylene oxides (i.e., alkylene oxide esters of fatty acids). These materials have the formula RCO (X) _n OH _wherein R is a C _10-30 alkyl group and X is -OCH ₂ CH ₂ - (i.e., derived from ethylene glycol or oxide) or -OCH ₂ CHCH ₃ - (I. E., Derived from propylene glycol or oxide) and n is an integer from about 6 to about 200. Other nonionic surfactants are the condensation products of two moles of fatty acids with alkylene oxides (i.e., alkylene oxide diesters of fatty acids). These materials have the general formula RCO (X) _n OOCR (in the formula, and R is a C _10-30 alkyl group, X is -OCH ₂ CH ₂ - or -OCH ₂ CHCH ₃ -, n is an integer from about 6 to about 100) Respectively. Other non-ionic surfactants are condensation products of fatty alcohols and alkylene oxides (i. E., Alkylene oxides of fatty alcohols). These materials have the formula R (X) nOR 'wherein R is a C _10-30 aliphatic group, X is -OCH ₂ CH ₂ - or -OCH ₂ CHCH ₃ - and n is an integer from about 6 to about 100 And R 'is H or a C _10-30 aliphatic group, examples of which include PEG 40 hydrogenated castor oil and PEG 60 hydrogenated castor oil, each of which is sold under the trade names " Cremophor RH 40 " and " Cremophor RH 60 " 20 is available from ICI (Wilmington, Mass., USA) under the tradename " Arlasolve 200 "; oleS-20 is available under the trade designation " Volpo N20 " from BASF (Parsippany, NJ, USA) Other non-osmotic surfactants are condensation products of alkylene oxides having both fatty acids and fatty alcohols (i.e., polyalkylene oxide moieties at the ends Esterified with a fatty acid and etherified with a fatty alcohol at the other end (that is, . Connected) the search] These materials have a general formula RCO (X) _n OR '(wherein, R and R' are C _10-30 alkyl group, X is -OCH ₂ CH ₂ - or a OCH ₂ CHCH _3, n is Such as ceteth-6, ceteth-10, ceteth-12, ceteareth-6, cetearates-10, ceteth- 10, stearates-12, PEG-6 stearate, PEG-10 stearate, PEG-100 stearate, PEG-12 stearate, PEG-6 stearate, PEG-80 glyceryl stearate, PEG-80 glyceryl tallow weight, PEG-10 glyceryl stearate, PEG-30 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG- Dilaurate, PEG-10 distearate, and mixtures thereof.
[168] Other nonionic surfactants useful herein are alkyl glucosides and alkyl polyglucosides as described in WO 98/18444, incorporated herein by reference. Further other useful nonionic surfactants include the polyhydroxy fatty acid amide surfactants described in detail in WO98 / 04241.
[169] Suitable other nonionic surfactants for use herein include: esters and polyesters, alkoxylated sugar esters and acylated polyesters, C ₁ -C ₃₀ fatty alcohols of C ₁ -C ₃₀ fatty acid ester, sugar, C ₁ -C ₃₀ fatty alcohols of C ₁ -C ₃₀ alkoxylated derivatives of fatty acid esters, C ₁ -C ₃₀ a of a fatty alcohol alkoxylated ether, C ₁ -C of polyglyceryl esters, polyol fatty acid C ₁ -C _{30 30} esters, C ₁ -C ₃₀ ethers of polyols, alkyl phosphates, polyoxyalkylene fatty ether phosphates, fatty acid amides, acyl lactylates and mixtures thereof. Examples of such non-silicon containing surfactants include: polysorbate 20, polyethylene glycol 5 soya sterol, stearates-20, ceteareth-20, PPG-2 methyl glucose ether distearate, polysorbate 80; Polysorbate 60 available under the trade designation " Tween 60 " from ICI (Wilmington, Mass., USA); Glyceryl stearate, sorbitan monolaurate, polyoxyethylene 4 lauryl ether sodium stearate, polyglyceryl-4-isostearate, hexyl laurate, PPG-2 methyl glucose ether distearate and mixtures thereof.
[170] Among the non-ionic surfactants, Cetheline-12, sucrose cocoate, Stearat-100, polysorbate 60, PEG-60 hydrogenated castor oil, isoceteth- And a mixture thereof.
[171] Other emulsifiers suitable for use herein are polyoxypropylene, polyoxyethylene ethers of fatty alcohols. These materials have the formula R (CH ₂ CHCH ₃ O) _x- , (CH ₂ CH ₂ O) _y -H wherein R is an OC ₁₀ -C ₃₀ alkyl group or a C ₁₀ -C ₃₀ alkyl group, 20, and y has an average value of 1 to 30), examples of which are available from Nikko Chemicals Co., Ltd .; PPG-6-decyltetradecet-30 commercially available under the trade name "Pen 4630" from Tokyo, JP (Ltd.); Nikko Chemicals Co. PPG-6-decyltetradecet-20 commercially available under the trade name " Pen 4620 " (Tokyo, JP); And PPG-5-Ceteth-20, marketed by Croda Chemicals Ltd (Goole, North Humberside, UK) under the trade name " Procetyl AWS ".
[172] Other emulsifiers useful herein are sorbitan or sorbitol fatty acid esters and sucrose fatty acid ester mixture-based fatty acid ester blends as detailed in WO 98/22085, incorporated herein by reference.
[173] Hydrophilic surfactants useful herein include any of a wide variety of cationic, anionic, zwitterionic and amphoteric surfactants, which are alternatively or additionally known in the art. See: McCutcheon's, Detergents and Emulsifiers, North American Edition (1986), published by Allured Publishing Corporation; U.S. Pat. No. 5,011,681, issued Apr. 30, 1991 to Ciotti et al; U.S. Pat. No. 4,421,769 issued to Dixon et al on Dec. 20, 1983; And US-A-3,755,560, issued Aug. 28, 1973 to Dickert et al .; These four references are incorporated herein by reference in their entirety.
[174] A wide variety of cationic surfactants are useful herein. Suitable cationic surfactants useful or useful herein are disclosed in WO 98/18444, incorporated herein by reference.
[175] A wide variety of anionic surfactants are also useful herein. Note: U.S. Pat. No. 3,929,678, Laughlin et al., Issued December 30, 1975, which is hereby incorporated by reference in its entirety. Representative anionic surfactants include alkyl isethionates (e.g., C ₁₂ -C ₃₀ ), alkyl and alkyl ether sulfates and salts thereof, alkyl and alkyl ether phosphates and salts thereof, alkylmethyltaurates (ie, C ₁₂ -C _30), and soaps (e.g., alkyl metal salts, for instance, sodium or potassium salt of a fatty acid) comprises.
[176] Amphoteric and zwitterionic surfactants are also useful herein. Examples of amphoteric and zwitterionic surfactants which can be used in the compositions of the present invention are, an aliphatic radical is straight or branched chain, and one of the aliphatic substituents about 8 to about 22 carbon atoms (preferably C ₈ -C ₁₈ ) And are widely disclosed as derivatives of aliphatic secondary and tertiary amines containing anionic water solubilizers such as carboxy, sulfonates, sulfates, phosphates or phosphonates. Examples are alkyliminoacetates, and iminodialkanoates and aminoalkanoates, imidazolinium and ammonium derivatives. Other suitable amphoteric and zwitterionic surfactants are those selected from the group consisting of betaines, sultaines, hydroxysultaines, alkyl sarcosinates (i.e., C ₁₂ -C ₃₀ ), and alkanoyl sarcosinates .
[177] The preformed single lamina sheet type device of the present invention may optionally contain a silicone-containing emulsifying agent or a surfactant. Various silicone emulsifiers are useful herein. These silicone emulsifiers are typically organically modified organopolysiloxanes known to those skilled in the art as silicone surfactants. Useful silicone emulsifiers include dimethicone copolyols. These materials are polydimethylsiloxanes modified to include polyether chains containing polyethylene oxide chains, polypropylene oxide chains, polyether side chains such as a mixture of these chains, and moieties derived from both ethylene oxide and propylene oxide . Other examples include alkyl modified dimethicone copolyols, i.e., compounds containing C ₂ -C ₃₀ hanging side chains. Still other useful dimethicone copolyols include materials having a wide variety of cationic, anionic, amphoteric and zwitterionic suspenders.
[178] Other optional ingredients
[179] The device of the present invention may comprise a wide variety of other optional components. These additional components should be pharmaceutically acceptable. The CTFA Cosmetic Ingredient Handbook: Second Edition, 1992, which is incorporated herein by reference in its entirety, discloses a wide variety of cosmetic and pharmaceutical ingredients which are commonly used in the cosmetic industry and which are suitable for use in the compositions of the present invention. Non-limiting examples of functional classes of ingredients are disclosed on page 537 of this reference. Examples of these and other functional classes include: abrasives, absorbents, antibiotics, anticaking agents, antidandruids, anti-swelling agents, antioxidants, biological additives, bleach activators, whitening agents, builders, An external analgesic, a fragrance, a film forming agent, a directional component, an insect repellent, a chelating agent, a chemical additive, a colorant, a cosmetic, a detergent, a denaturant, a dental treatment, a deodorant, Antioxidants, oxidative pigments, oxidizing agents, pest control ingredients, pH adjusting agents, pH buffers, pharmaceutical active agents, plasticizers, preservatives, radical scavengers, skins, hair or nail bleaches, skin, hair or nail conditioners, skin , Hair, nail penetration enhancers, stabilizers, surface conditioners, reducing agents, temperature suppressing agents, and warming agents.
[180] Aesthetic ingredients such as colorants, essential oils and skin, hair or nail removers may also be useful herein. Other optional components herein include pigments. Suitable pigments for use in the compositions of the present invention may be organic and / or inorganic. The term " dye " also includes materials with low color or gloss, such as matte finishes and also light scattering agents. Examples of suitable pigments are iron oxides, acyl glutamate iron oxides, titanium oxides, ultramarine blue, D & C dyes, carmine and mixtures thereof. Depending on the type of composition, mixtures of pigments are commonly used.
[181] The pH of the preformed single lamina sheet type device of the present invention is preferably from about 3 to about 9, more preferably from about 4 to about 8.
[182] The preformed single lamina sheet-like device of the present invention is a patch or mask having a size and shape adjusted to conform to the target area. Thus, the device of the present invention can have a size in the range of surface area of from about 0.25 cm 2 to about 1,000 cm 2. Preferably, the at least one surface dimension, preferably the two surface dimensions, of the device exceeds the depth of the device, preferably the surface dimension to depth of the device is from about 2: 1 to about 100: 1, From about 5: 1 to about 50: 1.
[183] As used herein, the term " surface dimension " refers to the dimension of the x or y axis, and the depth is measured along the z axis. The exact size and shape will depend on the intended use and product properties. Sheet molded devices herein are suitable for topical use on nails or epidermis, hair or scalp, human face or part thereof, legs, hands, arms, feet or human thorax. The device of the present application is of a different form, such as a square, circle, rectangle, ellipse or a compound of the above, such as a form that can be described as " semicircle ", " donut " The device formed to fit the face has a surface area in the range of about 0.25 cm 2 to about 500 cm 2, preferably about 1 cm 2 to about 400 cm 2. The patch or mask device according to the third aspect of the invention has a thickness of from about 0.5 mm to about 20 mm, preferably from about 1 mm to about 5 mm. The patch or mask device according to the second aspect of the present invention has a thickness of from about 0.5 mm to about 20 mm, preferably from about 0.5 mm to about 3 mm, in its thick portion, and from about 0.5 mm to about 17.5 mm, preferably from about 0.5 mm to about 2.5 mm.
[184] The preformed sheet-like device of the present invention may also be manufactured and used in the form of handwear, foorwear or body wrap. Typically, the handwarming will include the hand or gloves of any part thereof, and the footwear will comprise the foot or sock of any part thereof. As used herein, the term " glove " is intended to include the term " glove ". Preferably, the handwarming includes an intermediate portion, a one to four finger receiver portion connected to the middle portion, a thumb receiver coupled to the middle portion, a palm side, and a glove body including the opposite back. Preferably, the footwear comprises a hosiery body forming a tubular foot portion having a closed end and an open end. The inventive device may also be manufactured or used in the form of a body wrap. The body wrap is radially wrapped around any body portion having a longitudinal axis. The ends can be connected to each other, and the length can also be shortened to be partially wrapped. In either case, the wrap should exhibit good conformity to the part of the body. Typically, the portion of the body includes the user's back, upper arm, lower arm, upper leg, lower leg, neck and thorax.
[185] After use of the device, the device can be left in the target area for about 3 hours, preferably about 1 hour, more preferably less than 15 minutes. The preformed single lamina sheet type device can then be removed all at once.
[186] Depending on the beneficial agents (or beneficial agents) contained herein, the devices of the present invention may have one or more of the following uses: moisturizing skin, hair or nails, relieving fine lines and wrinkles; Treatment of cosmetic acne; Skin firming, kidney; softness; Exfoliation; Improving and / or equalizing skin tone and / or texture; Skin, hair or nail whitening; Tanning; Reduction of pores; Absorption or control of secretions; Protection and / or stabilization of skin, hair or nails, muscles, pain or pain; Reduction of puffiness and dark circles; Stimulation of wound restoration; Heating, refreshing or cooling skin, hair or nails; Inflammation treatment; Whitening of complexion; Congestion relief; Swelling reduction; Treatment of dermatological conditions; Cushioning; purification; direction; Bacterial or microbial growth reduction; recovery; Insect pests; Removal of unwanted hair, dirt or makeup; And pigmentation or bleaching of the target area to which the device is applied. Preferably, the preformed single thin sheet-like device of the present application is used herein to moisturize skin, hair or nails, alleviate fine lines and wrinkles; And cosmetic use to improve and / or equalize skin tone and / or texture.
[187] Manufacturing method
[188] The at least one beneficial agent and the at least one gelled polymeric gel former are treated with a gelling step to form a self-supporting, preformed, single sheet thin sheet device. The nature of the gelling step depends on the polymeric gel former used. For example, the gelling step may include the addition of metal ions to crosslink the polymer solution, or may include irradiation of ultraviolet radiation to produce a self-supporting gel.
[189] In many cases, the gelling step is achieved through cooling. This may be accomplished by heating the gel, one or more benefit agents and one or more gelling polymeric gel formers, together with any other existing components (or gel-forming mixture), to a primary temperature above the gel point of the gel- ; Placing the gel-forming mixture in an appropriately shaped mold; Gelation mixture at a secondary temperature that is cooler than the primary temperature below the gel point of the gel-forming mixture to produce a single thin sheet of self supporting device. In an alternative embodiment, the at least one beneficial agent and at least one gelled polymeric gel former and any other existing components are heated and placed in a mold that is once properly molded.
[190] In the formation of self-supporting devices, the components may be added together or sequentially in any order. The order of addition of the components may depend on its nature and characteristics. Preferably, one or more beneficial agents and one or more gelling polymeric gel formers are dissolved in the liquid sufficiently and then any other ingredients are added. The term " fully soluble " means that the gel-forming mixture appears to be substantially or completely transparent. The temperature of the gel-forming mixture is kept above the gel point until all ingredients are added. In an alternative embodiment, it may be advantageous to begin to lower the temperature of the gel-forming mixture prior to the addition of the final component.
[191] The at least one beneficial agent and the at least one gelling polymeric gel former at an elevated temperature for an effective period of time. The " effective " time is sufficient to provide sufficient time to completely (or substantially) dissolve one or more gelled polymeric gel formers in the liquid.
[192] In a preferred embodiment, the self-supporting device can be produced by injection molding. The fabricated device is more robust due to the smoother finish of the surface, which provides greater thermostability. An injection molding method for producing a self supporting device comprises injecting a gel forming mixture into a suitably shaped mold and maintaining the mixture at a primary temperature above the gel point of the gel forming mixture prior to the injection step; Cooling the gel-forming mixture to a secondary temperature below the gel point of the gel-forming mixture in a suitably shaped mold to form a single thin sheet of self supporting device.
[193] In an alternative injection molding method, the at least one beneficial agent and the at least one gelling polymeric gel-forming agent and any other ingredients, if present, are added continuously or in all at once or in any order. In injection molding, one or more benefit agents and one or more gelling polymeric gel formers are modified to be a fluid sufficient to readily feed the die in any conventional means, in addition to the injection molding method. A lubricant may be added to aid in the supply of the gel-forming mixture along the orifice of the extruder.
[194] The gel-forming mixture can be fed to a properly shaped mold with any of a variety of other known techniques, including specific gravity feed systems and air or mechanical injection systems. Injection molding is the most desirable technique due to the fluidity of the mixture and the low processing temperature. Extremely wide forming pressures can be used. Typical molding pressures are about 10 < ⁵ > Pa (1 atm) and about 5 x 10 < ⁶ > Pa (50 atm), although high or low pressures can be used according to the molding techniques used. An advantage of the present invention is the ability to shape the device of the present invention using low pressure.
[195] When achieving gelation through cooling, the shaping temperature, of course, must be below the gel point of the gel-forming mixture to make the self-supporting device. A suitable mold temperature can be achieved before, during, or after the mixture is fed to the mold. After the device is molded and cooled to a temperature below the gel point, the device is removed from the mold. Self-supported devices do not require any special handling during removal from the mold.
[196] The devices of the present invention, wherein the device has non-planar topography on at least one, preferably secondary, surface of the primary and secondary surfaces of the device, and non-planar topography includes two or more contoured regions that do not have the same average thickness simultaneously In a device according to the first or second or fourth aspect, the mold has at least one of the primary and secondary mold surfaces, and at least one of the primary and secondary mold surfaces is at least one negative image of the primary and secondary surfaces of the device itself At least one of the primary and secondary mold surfaces is a negative image of non-planar topography. Non-planar topography is a free-selective form, including, but not limited to, those illustrated in Figures 1-4, 6-7, 8-9 and 10-12 of the accompanying drawings. If the non-planar topography has periodicity, at least one of the primary and secondary mold surfaces has periodicity, which provides a negative image of the periodicity to at least one of the primary and secondary surfaces of the device itself.
[197] According to the first and third aspects of the present invention, the device has at least one, preferably secondary, surface of primary and secondary surfaces with non-planar topography comprising a textured surface which is a negative image of the textural surface, The negative image of the sex surface has a tissue defined as R _{a that} is greater than 10 탆. If the non-planar topography has periodicity, the textured surface has periodicity, which provides a negative image of the periodicity to at least one of the primary and secondary surfaces of the device itself. The process for its preparation comprises preparing a gel-forming mixture comprising at least one beneficial agent and at least one polymeric gel-former and optionally any components, and heating the mixture to a primary temperature above the gel point of the mixture to dissolve the gel- ; Disposing the mixture in an appropriately shaped mold having primary and secondary mold surfaces which are at least one negative image of the primary and secondary surfaces of the device itself; Pre-arranging a textured surface having at least one of the primary and secondary mold surfaces defined as R _a with _a negative image greater than 10 탆; Gelling the mixture to a second temperature that is cooler than the gel temperature of the gel-forming mixture below the first temperature; And removing tissue surfaces from the device. The removal step may occur during or after the gelling step. A textured surface is selected from the gases described above, wherein the negative image of the outer surface of the gas has an R _a of greater than 10 탆. The formed film is the preferred textured surface.
[198] In an alternative embodiment, the mixture is heated and once placed in a mold. In a further alternative embodiment, at least one of the primary and secondary mold surfaces is textured to form a textured surface by an etching method or any other known method.
[199] If the non-planar topography has periodicity on both the primary and secondary surfaces of the device, the pattern produced on both surfaces periodically as a result of the mold surface or the textured surface with periodicity may be aligned or intersected. Preferably, the pattern is crossed.
[200] The method also includes a method of making a single sheet-thin sheet-like device previously formed according to the first, second and third or fourth aspect of the present invention, the method comprising: providing at least one beneficial agent and at least one polymeric gel- If present, a gel forming mixture comprising any component; Heating the mixture to a primary temperature above the gel point of the mixture to dissolve the gel-forming mixture; Wherein the mixture is placed in a suitably shaped mold having at least one of the primary and secondary mold surfaces, at least one negative image of the primary and secondary surfaces of the device itself, and at least one topography of the primary and secondary device surfaces has the same average thickness Limit two or more contoured areas not simultaneously present; Pre-arranging a textured surface having at least one of the primary and secondary mold surfaces defined as R _a with _a negative image greater than 10 탆; Gelling the mixture to a second temperature that is cooler than the gel temperature of the gel-forming mixture below the first temperature; And removing the tissue surface from the device.
[201] In an alternative embodiment, the mixture is heated and once placed in a mold. In a further alternative embodiment, at least one of the primary and secondary mold surfaces is textured to form a textured surface by an etching method or any other known method.
[202] Assessment Methods
[203] Gel compression burst test
[204] The mechanical properties of the preformed single sheet metal sheet-like device of the present invention are evaluated through a compression failure test of the gel. The parameters of interest are the gel strength (as assessed by the compressive force required to rupture the molded gel cylinder) and the gel resilience (as measured by the degree of gel compression at break). A more detailed description of the test method is as follows.
[205] Extrusion failure tests are performed using a Stable Micro Systems (SMS) Texture Analyzer (TA), Model TA-XT2i (Godalming, Surrey, UK) available from Stable Micro Systems Ltd. Control the system through SMS's Texture Expert Exceed software running on Windows 98 (version 2.03). Attach a 100 mm diameter aluminum compression plate (P-100 probe) to the 50 Kg load cell. This is loaded from the TA probe carrier and the vertical reciprocating arm is placed under computer control.
[206] To make a test sample, the gel formulations of interest are prepared as described below. A precise cylindrical solid type gel disk (26 mm in diameter x 12 mm in depth) is formed in a correspondingly shaped die. The mold with the sample is sealed against evaporation during storage. The gel disk is stored at ambient temperature overnight. Each gel disc is removed from the mold immediately prior to testing and visually inspected for defects. Any gel disc with defects (e.g., trapped bubbles) is ignored if such defects can affect the evaluated mechanical properties. The flawless gel disc is then concentrated under the P-100 compression plate.
[207] Texture Expert Exceed Sets the software to Force / Compressive mode. The compression plate is preset to a starting height of 12.0 mm. Its descent rate is set to 0.8 mm / sec and the overall reciprocal distance is set to 10.8 mm (i.e., the evaluation point when the gel disk is compressed to 90% of its original height). The data is automatically collected at the force and position of the compression plate at a rate of 200 pps (points per second). The software is preset to achieve compression plate position at maximum force. The maximum force is the burst strength, i.e., the force required to rupture the gel disk. The distance traveled by the plate from its original starting height to the gel rupture represents the degree of deformation of the gel. At the rupture point, the maximum force is averaged over a sample (typically 5 replicates) and reported as Newton.
[208] In the gel point of the rupture, the uniaxial deformation (compression) is represented by the percentage of the originally formed height, that is, compression% = distance reciprocated by plate (mm) / 12 (original sample height, mm) . If the gel rupture does not occur at the end of the 10.8 mm stroke (i.e., 90% compression), the gel is classified as " non-ruptured " under the test conditions.
[209] Surface Roughness
[210] Surface topography is evaluated using the CADEYES Surface Analysis System (Medar, USA), a wave pattern interference technique, which is formed with a 30.7 탆 x-axis resolution, a 35.8 탆 y-axis resolution, and a 1.6 탆 z-axis resolution. The first or third aspect of the present invention can be achieved by making a Silicone Silicone Impression Material (Flexico Developments, UK) of a textured surface useful for the manufacture of a preformed single sheet metal sheet device according to the first or third aspect of the present invention. To produce a textured surface representation of the side device. Because the optical properties of the silicon mold material are more suitable for optical surface analysis, silicon templates are used instead of the actual preformed single sheet metal sheet device.
[211] A silicon mold is prepared as follows:
[212] 1. Silicon paste of a diameter circle of 2.54 cm (1 inch) is thoroughly mixed with 1 drop of catalyst for 1 minute.
[213] 2. Using a spatula, apply the silicone mixture to the textured surface and cure for an appropriate 7 minutes at room / ambient temperature.
[214] 3. After curing, remove the silicone mold from the textured surface and analyze.
[215] The data reported for the description of the surface roughness of the silicon mold prototype of the structured surface of the device of the first or third aspect of the present invention is R _a (surface-based mean deviation from the most suitable surface), where R _a is (Where z is the absolute value minus the elevation measured at that point from the most appropriate elevation at one point at one point and the most appropriate elevation mapped at one point is the most appropriate elevation for the surface measured at that point The height of the plane). The data reported for the description of the surface roughness also includes R _q (surface-mean near-mean-square deviation from the most suitable surface) and R _z (10-point roughness).
[216] R _q is the mean square deviation of the surface fibrils from the most suitable plane
[217]
[218] R _z is the 10-point illumination averaged over all scan lines in the x-direction,
[219] _{R z = ((S 1 +} S 3 + S 5 + S 7 + S 9) - (S 2 + S 4 + S 6 + S 8 + S 10)) / 5
[220] _{(Wherein, S 1, S 3, S} 5, S 7, S 9 is the five highest peaks from the correct side of the scan lines _{S 2, S 4, S 6} , S 8, S 10 , depending on the scan line Which is the lowest score from the most suitable side). The most suitable surface as described herein is automatically mapped by the CADEYES Surface Analysis System, where i is an index that refers to a specific point analyzed and n is the total number of points analyzed, for example, 1 cm ² area , N is 90,987.
[221] Although the surface topography of the sample is obtained using a moiré interfering technique, a surface profiling technique (e. G., X and y axis resolution less than 40 micrometers; z axis resolution less than 2 micrometers) For example, a stylus profilometry, laser profilometry, laser profilometry, or fringe projection) can be used to obtain surface topography for making the data. An alternative measure of R _a and R _q is described in the method described in ISO 4287 (1997), where R _a is defined as the arithmetic mean deviation of the assessed profile and R _q is defined as the root mean square deviation of the assessed profile .
[222] Surface luster
[223] 0.8% agarose, 0.3% Kelgum (a 1: 1 mixture of xanthan gum and locust bean gum, supplied by Kelco, San Diego, CA), 20% glycerin, 10% niacinamide, 5% butyleneglycol, 0.15% Nipagin A (ethylparaben supplied by Nipa Laboratories, Inc., Delaware, Del.), 0.1% Hampene Na ² (supplied by Lexington Chemical, Sodium EDTA), 62.62% deionized water. The tissue surface is removed and once the gel structure is established. Then, on the textured surface of the preformed single sheet metal sheet-like device according to the first or third aspect of the present invention, gloss evaluation (i.e., surface reflectance) on the opaque (black) section of the Leneta Card available from The Leneta Company ). Surface reflectance is evaluated using a BYK-Gardner Micro Tri-Gloss meter (Maryland Silver Spring, BYK Gardner) set to display 20 degrees (20 degrees), 60 degrees (60 degrees) and 85 degrees (85 degrees).
[224] Gel transparency
[225] The gel transparency is evaluated by assessing the visibility of the text printed through the device according to the invention. Print letters in English characters (capital letters) on transparency film (Universal Office supplied) using a LaserJet 4 Plus printer (Hewlett Packard) equipped with Microsoft Word Aral Font and black ink cartridge I make it. A transparent film printed with a font size ranging from 4 to 28 points is produced. The printed transparency is then spread over a sheet of white paper to identify a uniform background and all samples are assessed under normal indoor light emission conditions.
[226] A gel sample of interest is formed to produce a gel disk having a thickness (depth) of 7 mm. The gel disk is placed on a transparent film printed in 4-font size, and the visibility of printed characters is evaluated through a gel disk. If the text is hard to read through the gel disk, change the disk to the next largest font size and repeat the process. The method is repeated until the font size is reached to an extent that is easy to read through the gel. The smallest font size that is then easy to read through the gel sample is designated as the " transparency titer " for the gel. The preferred " transparency titer " for the gel used to make the device of the present invention is 10 font size, more preferably 7 font size and particularly preferably 4 font size.
[227] Example
[228] The present invention is illustrated by the following examples.
[229] Examples 1 - 3
[230] 123
[231] Ingredients% w / w% w / w% w / w
[232] Agarose-0.40.8
[233] Locust bean gum-0.27-
[234] I met konjac 0.3--
[235] Xanthan gum 0.10.13-
[236] Kelgum (R) ^{1 -} 0.3
[237] Gellan gum 1.00.4-
[238] Glycerin 20.020.015.0
[239] Butylene glycol 5.0-8.0
[240] Panthenol 1.02.02.0
[241] Niacinamide-5,0-
[242] Sucrose
[243] Poly Cotton Seed Eight - 0.5
[244] Polysorbate 60--0.2
[245] Dimethicone copolyol 0.020.02-
[246] Benzyl alcohol -0.30.2
[247] Ethyl paraben 0.20.1-
[248] Propyl paraben-0.05-
[249] The sodium EDTA-0.1-
[250] Calcium chloride 0.10.08-
[251] 100 100 Sum 100 100
[252] Bursting force / N8273102
[253] % Compression 264458
[254] Gaseous paper ² -
[255] ¹ Kelgum (R) is a 1: 1 mixture of xanthan gum and locust bean gum supplied by Kelco, San Diego, San Diego, USA.
[256] ² paper is supplied by Kimberley-Clark Corp., Roswell, GA, USA. From " Kimwipes EX-L ".
[257] The polysaccharide gum is mixed with water to form a uniformly dispersed mixture which can be promoted by pre-dispersing the polysaccharide in a non-solvent such as a polyhydric alcohol, and any optional ingredients are added. The mixture is heated with stirring to a primary temperature above the gel point of the mixture (about 90 ° C) to fully hydrate the polysaccharide gum. The liquid gel is then dispersed in a mold to be suitably molded (Example 3). The devices of Examples 1 and 2 are injection molded into a mold to be suitably molded. Injection molding is preferable. This eliminates any disadvantages that can be introduced by cutting the gel and thus improves the robustness of the device. Injection molding also makes the easily formed device into a three-dimensional structure. The liquid gel is then cooled to a secondary temperature that is cooler than the primary temperature (ambient temperature) below the gel point of the mixture to form a gel structure. The device is then removed from the mold. The devices of Examples 1-3 are illustrated respectively in Figures 1-3 of the accompanying drawings. The device of the present disclosure is then packaged in a material with low water vapor permeability to minimize drying of the device during storage. Packaging suitable for the device herein includes a small bag or a sealing dish. If the device is packaged in a small bag, it is desirable to protect it before use. The protection can be provided as a gas or release liner, such as a plastic film, which provides for easy release of the device.
[258] If gas is used (Example 1), it can be placed in a mold that is suitably molded prior to dispersion of the gel or placed on the surface of the liquid gel during the cooling step.
[259] In some compositions, metal ions (e.g., Ca ²⁺ , K ⁺ ) can be included in the formulation to increase the gel strength of the device (Examples 1 and 2). In this case, the metal ions are added in the form of an aqueous solution and immediately stirred in a liquid gel before the dispersing step.
[260] The process can be modified as required depending on the nature of the optional additional ingredients. For example, if a non-aqueous component is present, the liquid gel may be immediately homogenized prior to the mold or template to identify a dispersion of the non-aqueous component. Similarly, if a thermosensitive component is incorporated, the formulation should be cooled to a suitable temperature (depending on the constituent) and the heat sensitive component added at this stage after the decolorization step.
[261] The liquid gel can be degassed, for example, in vacuo to remove bubbles dispersed in the liquid. The degassing step, if carried out, may be immediately in the final stage prior to dispersion of the liquid gel.
[262] As indicated above, the preformed sheet-like device here has excellent strength and resilience.
[263] Example 4
[264] A combination of preformed sheet-like devices containing 50/50 (w / w) silicone gel forming agent and ascorbic acid and derivatives thereof as benefit agent is prepared. Anhydrous Ammonia 0.025 part, essentially (CH _{3) 3} SiO _1/2 units and to SiO _4/2 units of from about 0.75: 1 is made of a molar ratio of about 2.7% by weight based on the solid measured by FTIR (ASTM E-168) 67 parts of a 70% by weight xylene solution of a hydroxyl-containing siloxane resin copolymer, 31 parts of a hydroxyl-terminated polydimethylsiloxane having a viscosity of about 13,500 cP (mP 占 퐏) at 25 占 폚 and 2 parts of 115 RTI ID = 0.0 > 120 C < / RTI > After cooling, the mixture is heated to 140 < 0 > C for 1 hour to remove any excess ammonia.
[265] Next, using a Lee stile steel tilt kettle equipped with a built-in Eppinbach high-end mixer for 17 minutes, the silicon mass was treated with the same weight of ascorbic acid and its derivatives (ultrafine powder , Hoffman-LaRoche).
[266] The silicon solution is transferred to a suitably shaped mold and air dried overnight to evaporate the solvent. The generating device is removed from the mold and packed. It has been found that silicone-containing preformed sheet-like devices are suitable for delivering ascorbic acid and derivatives thereof to the skin, hair or nail as an advantageous agent.
[267] Example 5
[268] (50 parts, dry weight) of a medical grade acrylic pressure sensitive adhesive (Draize scale score 0-1), dissolved in ethyl acetate and toluene, in an amount of 50 parts (ascorbic acid and its derivatives and sodium ascorbate, 22 (weight / weight) ratio) to form a cosmetically effective adhesive matrix. This is transferred to a suitably shaped mold and then cured at 121.2 ° C. The preformed sheet-like device is suitable for delivering one or more benefit agents to the skin, hair or nail.
[269] Example 6
[270] Component% w / w
[271] Aga 0.6
[272] Agarose 0.3
[273] Locust bean gum 0.1
[274] 0.2 meet with konjac
[275] Xanthan gum 0.1
[276] Glycerin 15.0
[277] Panthenol 3.0
[278] Polysorbate 600.08
[279] Benzyl alcohol 0.3
[280] Ethyl paraben 0.1
[281] Propyl paraben 0.05
[282] 100
[283] Breaking force / N78
[284] % Compression 58
[285] The polysaccharide gum is mixed with water to form a homogeneous dispersion and optional ingredients are added. The blending of the homogeneous dispersion liquid can be promoted by non-solvent, for example, by previously dispersing the polysaccharide in the polyhydric alcohol. The mixture is heated to about < RTI ID = 0.0 > 90 C < / RTI > with stirring to fully hydrate the polysaccharide gum. The liquid gel is degassed, for example, in vacuo to remove the dispersed bubbles in the liquid. The liquid gel is then dispersed in a suitably shaped mold and then cooled to ambient temperature to form a gel structure. The device can then be removed from the mold. Instead, a liquid gel can be cast into a sheet and a suitably molded device can be cut from the gel sheet. The device of Example 6 is illustrated in Figure 4 of the accompanying drawings. The device is then packaged in a material having water vapor impermeability to minimize drying of the device during storage.
[286] The duplicate of the device is then evaluated for surface roughness (Table 1) and surface reflectance (Table 2) using various textured surfaces. The tissue surface may be contacted with the device during or prior to gelation of the liquid gel.
[287] Table 1 - Surface roughness of silicon castings
[288] The textural surface R _a R _q R _z
[289] None 4.856.3214.13
[290] 60 mesh, X-7189 ² 21.1034.3793.93
[291] 40 hex, X-2S137 ² 92.27133.51353.78
[292] VFE, 3.4 miles, X-15928 ² 160.22189.26441.45
[293] DRI-WEAVE, pattern # 35 / 7171.18206.07527.44
[294] Hydroformed Film ¹ 315.26360.85786.01
[295] ¹ Hydroformed films have both micro and macro pores as described in U.S. Pat. No. 4,609,518 issued to Curro et al., Issued on Sep. 2, 1986. Preferably, the macropores have a teardrop pattern with a 12% open area distributed in a pattern having 24 macropores / cm ² , wherein the base of each macropore is 1.54 mm ² and the tip has a diameter of 0.3 mm ² and micropores are formed on a screen having a 100 mesh pattern.
[296] ² Tredegar Film Products, 1100 Boulders Parkway, Richmond, VA, USA 23225.
[297] All the textured surfaces described above with respect to the gas are preferably formed films.
[298] A negative image of all suitable tissue surfaces as defined above will have an R _a greater than 10 탆, preferably greater than 20 탆, when measured as described above. A preferred range for a negative image of the textured surface for a device of the present invention is R _a greater than 10 탆 and less than 316 탆 when measured as described above. A negative image of a suitable tissue surface as defined herein will have an R _q greater than 7 탆, preferably greater than 30 탆 and / or most preferably less than 375 탆. A negative image of a suitable textured surface will have an R _z of more than 15 μm, preferably more than 75 μm, more preferably more than 90 μm and / or most preferably less than 800 μm.
[299] Table 2 - Surface reflectance of the textured surface
[300] Tissue surface 20 ° 60 ° 85 °
[301] None 4864.872.8
[302] 60 mesh, X-7189 ² 0.94.04.3
[303] 40 hex, X-2S137 ² 1.87.24.3
[304] DRI-WEAVE, pattern # 35 / 72.514.317.2
[305] Hydroformed film ¹ 0.30.80.35
[306] VFE, 3.4 miles, X-15928 ² 2.723.619.2
[307] ¹ Hydroformed film has both micro and macro pores as described in U.S. Pat. No. 4,609,518 issued to Kuro et al., Issued on Sep. 2, 1986. Preferably, the macropores have a teardrop pattern with a 12% open area distributed in a pattern having 24 macropores / cm ² , wherein the base of each macropore is 1.54 mm ² and the tip has a diameter of 0.3 mm ² and micropores are formed on a screen having a 100 mesh pattern.
[308] ² Tredegar Film Products, 1100 Boulders Parkway, Richmond, VA, USA 23225.
[309] All textured surfaces as defined herein will have desirable gloss levels in the range of <40, <58 and <65 for 20 °, 60 ° and 85 ° geometry, respectively. The preferred range of gloss for the devices of the present invention is 0-10, 0-30, and 0-25 for 20 °, 60 °, and 85 ° geometry, respectively. The most preferred gloss ranges are 0 - 5, 0 - 25 and 0 - 20 for the 20 °, 60 ° and 85 ° geometries, respectively.
[310] Example 7
[311] % (w / w)
[312] Agarose 0.9
[313] Glycerin 20.0
[314] Butylene glycol 5.0
[315] Ethyl paraben 0.15
[316] Sodium EDTA 0.1
[317] 100
[318] The polysaccharide gum is mixed with water to form a homogeneous dispersion and optional ingredients are added. The formulation of the homogeneous dispersion can be promoted by previously dispersing the polysaccharide in a non-solvent, for example, a polyhydric alcohol. The gel-forming mixture is heated to about 90 캜 with stirring to fully hydrate the polysaccharide gum. (E. G., In vacuo), the liquid gel forming mixture is transferred to a suitably shaped mold (e. G., A mold formed to produce the patch device illustrated in Figures 6 and 7 of the accompanying drawings). The gel transparency of the device is assessed as described above and its transparency is 4 font size.

权利要求:
Claims (27)
[1" claim-type="Currently amended] A single sheet-metal device (10, 110, 210, 310, 410, 510, 610, 710, 810 define a primary and secondary spaced isolated surface 14, 114, 214, 314, 414, 514, 614, 714, 814; 16, 116, 216, 316, 416, 516, 616, 716, (12, 112, 212, 512, 612, 712, 812), At least one beneficial agent and at least one polymeric gel former; Having a non-planar topography on at least one of the primary and secondary surfaces.
[2" claim-type="Currently amended] The primary and secondary space-isolated surfaces (14,114, 14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,16,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,16,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,14,16,14,16,14,14,16,14,14,14,12,14,12, 214, 314, 514, 614, 714, 814; 16, 116, 216, 316, 516, 616, 716, 816; At least one beneficial agent and at least one polymeric gel former; Having a non-planar topography on at least one of the primary and secondary surfaces, wherein the non-planar topography comprises at least two contoured regions (22, 122, 222, 322, 522, 622, 722 , 822, 18, 118, 818, 20, 220, 320, 524, 624, 724).
[3" claim-type="Currently amended] The device of claim 2, wherein one of the two or more contoured zones comprises a rim (18, 118, 818) adjacent the periphery (12, 112, 822).
[4" claim-type="Currently amended] 4. The device of claim 2 or 3, wherein one of the two or more contoured zones comprises one or more ridges (20, 220, 320) proximate the periphery (12, 212).
[5" claim-type="Currently amended] 5. The device according to any one of claims 2 to 4, wherein one of the two or more contoured zones comprises a symbol mark.
[6" claim-type="Currently amended] 6. A method according to any one of claims 2 to 5, wherein the secondary surface is the periphery of the skin, hair or nail and the secondary surface (16, 116, 216, 316, 516, 616, 716, 816) Wherein the negative image of the tissue surface has a tissue defined as R _a of greater than 10 탆.
[7" claim-type="Currently amended] The method of claim 6 wherein the primary surface is adjacent to the skin, hair or nail and the primary surface (14, 114, 214, 314, 514, 614, 714, 814) comprises a textured surface which is a negative image of the tissue surface has a non-planar topography, a negative image of the tissue surface property is defined as a device having a tissue of _a R 10 ㎛ than that.
[8" claim-type="Currently amended] A method of manufacturing a preformed single sheet thin sheet device according to any one of claims 1 to 7, characterized in that the non-planar topography comprises two or more contoured zones or zones of negative (The negative image of the tissue surface has a tissue defined as R _a in excess of 10 [mu] m); Or both; Providing a gel-forming mixture comprising at least one beneficial agent and at least one gelling polymeric gel-forming agent in a mold having at least one surface that is a negative image of each non-planar topography; And then gelling the gel-forming mixture.
[9" claim-type="Currently amended] 13. The method of claim 12 wherein the providing step is injection molding.
[10" claim-type="Currently amended] 14. The method of claim 12 or claim 13, wherein the non-planar topography is on the secondary surface (16, 116, 216, 316, 516, 616, 716, 816) and has two or more contours At least one of the zones 22, 122, 222, 322, 522, 622, 722, 822; 18, 118, 818; 20, 220, 320; 524, 624, 724, Comprising a textured surface.
[11" claim-type="Currently amended] 15. A device according to any one of claims 12 to 14, wherein the device additionally comprises non-planar topography on the primary surfaces (14, 114, 214, 314, 514, 614, 714, 814) a method having the organization defined by the R _a comprises a textured surface of a negative image of the surfaces and tissue, tissue St. negative image of the surface is greater than 10 ㎛.
[12" claim-type="Currently amended] A pre-formed single-piece sheet-like device (410, 810) for delivering an benefit agent to the skin, hair or nail, comprising at least one beneficial agent and at least one polymeric gel former; Wherein the primary surfaces 414 and 814 are adjacent to the skin, hair or nail in use and the secondary surfaces 416 and 816 are located adjacent to the primary surface 414 and 814, ) having the non-planar topography, the nonplanar topography is a device having the organization defined by R _a of the surface including the organization of a negative image of the tissue and the surfaces, the surfaces tissue negative image is greater than the 10 ㎛.
[13" claim-type="Currently amended] The device according to any one of claims 1 to 7 or 12, wherein the device is combined with a gas.
[14" claim-type="Currently amended] 14. A device according to any one of claims 1 to 7, 12 or 13, wherein the at least one polymeric gel-forming agent is a water-soluble polymeric gel-former.
[15" claim-type="Currently amended] 15. A method according to any one of claims 1 to 7 or 12 to 14, wherein the secondary surfaces (316, 416, 816) are less than 40, preferably less than 10, most preferably less than 5, / RTI &gt;
[16" claim-type="Currently amended] 16. The device of claim 15, wherein the secondary surface has a 60 degree gloss of less than 58, preferably less than 30, most preferably less than 25.
[17" claim-type="Currently amended] 17. The device of claim 15 or 16, wherein the secondary surface has an 85 占 gloss of less than 65, preferably less than 25, most preferably less than 20.
[18" claim-type="Currently amended] 18. A device according to any one of claims 12 to 17, wherein at least one of the primary and secondary surfaces has two or more contoured contoured regions without simultaneously having the same average thickness.
[19" claim-type="Currently amended] 19. A device according to any one of claims 1 to 7 or 12 to 18, having a transparency titer of less than 10 font size, preferably less than 7 font size, most preferably less than 4 font size.
[20" claim-type="Currently amended] 19. Device according to any one of claims 1 to 7 or 12 to 18, in the form of a patch.
[21" claim-type="Currently amended] 20. Device according to any one of claims 1 to 7 or 12 to 20, packaged in a sealed protective wrapping paper.
[22" claim-type="Currently amended] 22. A method of making a preformed single sheet thin sheet device according to any one of claims 1 and 12 to 21, wherein the primary mold surface is a negative image of the primary surface (814) Providing a gel-forming mixture comprising an benefit agent and at least one gelling polymeric gel former; Contacting the tissue surface with a secondary surface (816) of the gel-forming mixture; Gelling the gel-forming mixture; And removing the tissue surface from the device.
[23" claim-type="Currently amended] 23. The method of claim 22, wherein the topography of the primary mold surface two or more drawn section contour not having the same mean thickness at the same time; is defined as R _a of the primary surface and / or 10 ㎛ than that define (822 824), tissue &Lt; / RTI &gt; wherein the negative image is a negative image of a textured surface.
[24" claim-type="Currently amended] 24. A method according to any one of claims 8 to 11 or 22 or 23, further comprising sealing the device to a protective wrapper.
[25" claim-type="Currently amended] Comprising contacting the skin, hair or nail with a device according to any one of claims 1 to 7 and 12 to 21 comprising at least one cosmetic benefit agent and at least one polymeric gel former , Wherein the at least one cosmetic benefit agent is delivered to the skin, hair or nail.
[26" claim-type="Currently amended] 22. A method according to any one of claims 1 to 7 or 12 to 21, wherein the nail or skin, hair or scalp, the human face or part thereof, leg, arm, hand, foot or body A preformed single sheet-thin sheet-like device in the form of a mask or patch having a size and shape.
[27" claim-type="Currently amended] 21. A handheld electronic device according to any one of claims 1 to 7 or 12 to 21, comprising: a handwear; Footwear; And a body wrap. &Lt; Desc / Clms Page number 13 &gt;

类似技术:

---

公开号 | 公开日 | 专利标题

---

US8353399B2|2013-01-15|Preparation-at-use device comprising pre-formed hydrogel product

---

JP4806633B2|2011-11-02|Galactomannan hydrocolloid

---

ES2269379T3|2007-04-01|Supply system with membrane.

---

US6641825B2|2003-11-04|Skin cleansing gel having a heating effect

---

KR101919029B1|2018-11-15|Thickened amino acid surfactant compositions and methods therefor

---

EP1600143B1|2019-07-10|SKIN PREPARATION FOR EXTERNAL USE CHARACTERIZED BY CONTAINING SUGAR DERIVATIVE OF a,a-TREHALOSE

---

US6858202B2|2005-02-22|Detergent compositions with enhanced depositing, conditioning and softness capabilities

---

US6274155B1|2001-08-14|Nonwoven sheet and film containing water absorbent keratin

---

TWI652066B|2019-03-01|For skin rejuvenation peptides and methods of use

---

ES2272239T3|2007-05-01|Foaming oleaginous compositions.

---

CN105664223B|2018-12-04|Cosmetic preparation, skin preparations for extenal use and medical instrument

---

JP3405737B2|2003-05-12|Hair cosmetic and treatment method

---

RU2458679C2|2012-08-20|Dispersed glyoxal-processed cationogenic polygalactomannans

---

CA2716765C|2017-04-04|Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof

---

TWI354565B|2011-12-21|Films comprising a plurality of polymers

---

RU2419412C2|2011-05-27|Composition for personal cleaning

---

JP2011510065A|2011-03-31|Personal care compositions in the form of articles

---

CA2502391C|2012-07-10|Product for treating the skin

---

AU756691B2|2003-01-23|Cleansing articles for skin and/or hair which also deposits skin care actives

---

US6277797B1|2001-08-21|Dispersed amorphous silica as oil in water stabilizer for skin cleansing liquid composition

---

CN104918603A|2015-09-16|Skin-exterior anti-ageing composition and production method therefor

---

EP1563831B1|2015-09-02|External composition for skin

---

CN101056604B|2013-02-13|Treatment articles capable of conforming to an underlying shape

---

JP5436778B2|2014-03-05|Cationic polygalactomannans with high degree of substitution for skin care products

---

JP4157840B2|2008-10-01|Process for making preforms

同族专利:

---

公开号 | 公开日

---

AU3246000A|2001-01-22|

---

MXPA02000267A|2004-05-21|

---

BR0012233A|2002-03-26|

---

CN1373653A|2002-10-09|

---

WO2001001816A1|2001-01-11|

---

AU4340900A|2001-01-22|

---

WO2001001952A1|2001-01-11|

---

CZ200236A3|2002-06-12|

引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

法律状态:
1999-07-06|Priority to USPCT/US99/15201

---

1999-07-06|Priority to US9915201

---

2000-04-12|Priority to PCT/US2000/009682

---

2000-04-12|Priority to USPCT/US00/09682

---

2000-06-30|Application filed by 데이비드 엠 모이어, 더 프록터 앤드 갬블 캄파니

---

2000-06-30|Priority to PCT/US2000/018108

---

2002-04-13|Publication of KR20020027478A

优先权:

---

申请号 | 申请日 | 专利标题

---

USPCT/US99/15201|1999-07-06|

---

US9915201|1999-07-06|

---

PCT/US2000/009682|WO2001001952A1|1999-07-06|2000-04-12|Devices|

---

USPCT/US00/09682|2000-04-12|

---

PCT/US2000/018108|WO2001001951A1|1999-07-06|2000-06-30|Sheet-like devices|